Anti-inflammatory effects of a Houttuynia cordata supercritical extract

被引：30

作者：

Shin, Sunhee ^{[1
,2
]}

Joo, Seong Soo ^{[4
]}

Jeon, Jeong Hee ^{[1
,2
]}

Park, Dongsun ^{[1
,2
]}

Jang, Min-Jung ^{[1
,2
]}

Kim, Tae-Ook ^{[5
]}

Kim, Hyun-Kyu ^{[5
]}

Hwang, Bang Yeon ^{[3
]}

Kim, Ki-Yon ^{[6
]}

Kim, Yun-Bae ^{[1
,2
,6
]}

机构：

[1] Chungbuk Natl Univ, Coll Vet Med, Cheongju 361763, South Korea

[2] Chungbuk Natl Univ, Vet Med Res Inst, Cheongju 361763, South Korea

[3] Chungbuk Natl Univ, Coll Pharm, Cheongju 361763, South Korea

[4] Gangneung Wonju Natl Univ, Div Marine Mol Biotechnol, Kangnung 210702, South Korea

[5] Rexgene Biotech, Life Sci Res Inst, Cheongwon 368885, South Korea

[6] Univ British Columbia, Dept Med, Vancouver, BC V6T 2B5, Canada

来源：

JOURNAL OF VETERINARY SCIENCE | 2010年 / 11卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

carrageenan; dexamethasone; Houttuynia cordata extract; indomethacin; inflammation; THUNB; INFLAMMATION;

D O I：

10.4142/jvs.2010.11.3.273

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Anti-inflammatory effects of Houttuynia cordata supercritical extract (HSE) were investigated in a carrageenan-air pouch model. HSE (200 mg/kg, oral) suppressed exudation and albumin leakage, as well as inflammatory cell infiltration. Dexamethasone (2 mg/kg, i.p.) only decreased exudation and cell infiltration, while indomethacin (2 mg/kg, i.p.) reduced exudate volume and albumin content. HSE lowered tumor-necrosis factor (TNF)-alpha and nitric oxide (NO), as well as prostaglandin E-2 (PGE(2)). Dexamethasone only reduced TNF-alpha and NO, while indomethacin decreased TNF-alpha and PGE(2). The suppressive activity of HSE on NO and PGE(2) production was confirmed in RAW 264.7. These results demonstrate that HSE exerts anti-inflammatory effects by inhibiting both TNF-alpha-NO and cyclooxygenase II-PGE(2) pathways.

引用

页码：273 / 275

页数：3

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