Temperature-responsive cell culture surfaces for regenerative medicine with cell sheet engineering

被引：223

作者：

Yamato, Masayuki ^{[1
]}

Akiyama, Yoshikatsu ^{[1
]}

Kobayashi, Jun ^{[1
]}

Yang, Joseph ^{[1
]}

Kikuchi, Akihiko ^{[1
]}

Okano, Teruo ^{[1
]}

机构：

[1] Tokyo Womens Med Univ, Inst Adv Biomed Engn & Sci, Shinjuku Ku, Tokyo 1628666, Japan

来源：

PROGRESS IN POLYMER SCIENCE | 2007年 / 32卷 / 8-9期

关键词：

cell-based therapy; cell sheet engineering; temperature-responsive culture dishes; porous membrane;

D O I：

10.1016/j.progpolymsci.2007.06.002

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

We have developed a novel strategy for regenerative medicine to recover tissue functions by using temperature-responsive cell culture surfaces. To overcome the limits of conventional methods such as the use of single-cell suspension injection and the use of biodegradable polymer scaffolds, we have applied transplantable cell sheets fabricated with temperature-responsive culture surfaces for cell delivery. Here, we summarize the development of the next generation of temperature-responsive cell culture surfaces using modifications of the polymer coating to allow for rapid cell sheet recovery-improved culture conditions, such that animal-derived products can be eliminated; and altered phase transition temperatures to produce patterned cell sheets. These designs allow for the reconstruction of more complex tissues to potentially treat a wide range of diseases. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1123 / 1133

页数：11

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