Synthesis and antitumor activities of novel bis-quinazolin-4(3H)-ones

被引：16
|
作者：
Rahmannejadi, Nasrin [1 ,2 ]
Yavari, Issa [3 ]
Khabnadideh, Soghra [4 ]
机构：
[1] Islamic Azad Univ, Dept Chem Sci, Tehran, Iran
[2] Islamic Azad Univ, Res Branch, Tehran, Iran
[3] Tarbiat Modares Univ, Dept Chem, POB 14115-175, Tehran, Iran
[4] Shiraz Univ Med Sci, Pharmaceut Sci Res Ctr, Shiraz, Iran
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2020年 / 57卷 / 03期
关键词：
BREAST-CANCER; DERIVATIVES; QUINAZOLINONES; 2-AMINOBENZAMIDES;
D O I：
10.1002/jhet.3749
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
With the aim of obtaining new antitumor agents, a series of bis-quinazolin-4(3H)-ones (3a-3 f) were designed and synthesized. These products contain 4-oxo-1,2,3,4-tetrahydro-quinazoline and 3H-quinazolin-4-one moieties linked together via a propyl chain. Cytotoxic activities of 3a-3 f were evaluated against lung adenocarcinoma (A549), breast carcinoma (MCF-7) and ovarian cancer (SKOV3) cell lines using MTT method. Cisplatin was used as a positive control. Among the tested compounds 3a, 3b, and 3e showed the best cytotoxic activities against all cancerous cell lines with IC50 values even less than cisplatin. Compounds 3d and 3f also showed desirable cytotoxic activities especially against A549 and MCF-7.
引用
收藏
页码：978 / 982
页数：5
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