Synthesis and antitumor activities of novel bis-quinazolin-4(3H)-ones

被引：16
|
作者：
Rahmannejadi, Nasrin [1 ,2 ]
Yavari, Issa [3 ]
Khabnadideh, Soghra [4 ]
机构：
[1] Islamic Azad Univ, Dept Chem Sci, Tehran, Iran
[2] Islamic Azad Univ, Res Branch, Tehran, Iran
[3] Tarbiat Modares Univ, Dept Chem, POB 14115-175, Tehran, Iran
[4] Shiraz Univ Med Sci, Pharmaceut Sci Res Ctr, Shiraz, Iran
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2020年 / 57卷 / 03期
关键词：
BREAST-CANCER; DERIVATIVES; QUINAZOLINONES; 2-AMINOBENZAMIDES;
D O I：
10.1002/jhet.3749
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
With the aim of obtaining new antitumor agents, a series of bis-quinazolin-4(3H)-ones (3a-3 f) were designed and synthesized. These products contain 4-oxo-1,2,3,4-tetrahydro-quinazoline and 3H-quinazolin-4-one moieties linked together via a propyl chain. Cytotoxic activities of 3a-3 f were evaluated against lung adenocarcinoma (A549), breast carcinoma (MCF-7) and ovarian cancer (SKOV3) cell lines using MTT method. Cisplatin was used as a positive control. Among the tested compounds 3a, 3b, and 3e showed the best cytotoxic activities against all cancerous cell lines with IC50 values even less than cisplatin. Compounds 3d and 3f also showed desirable cytotoxic activities especially against A549 and MCF-7.
引用
收藏
页码：978 / 982
页数：5
相关论文
共 50 条
  • [1] Synthesis of Quinazolin-4(3H)-ones via a novel approach
    Akbari, Ali
    Zahedifar, Mahboobeh
    JOURNAL OF SAUDI CHEMICAL SOCIETY, 2023, 27 (02)
  • [2] SYNTHESIS OF BENZOXAZOLYLTHIOMETHYL AND BENZTHIAZOLYLTHIOMETHYL QUINAZOLIN-4(3H)-ONES
    Rafeeq, Mohammad
    Reddy, Chittireddy Venkata Ramana
    Dubey, Pramod Kumar
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2015, 190 (11) : 1857 - 1864
  • [3] Synthesis of 2, 3-Disubstituted-Quinazolin-4-(3H)-ones
    Patil, D. A.
    Patil, P. O.
    Patil, G. B.
    Surana, S. J.
    MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2011, 11 (08) : 633 - 641
  • [4] Quinazolin-4(3H)-ones and 5,6-Dihydropyrimidin-4(3H)-ones from β-Aminoamides and Orthoesters
    Gavin, Joshua T.
    Annor-Gyamfi, Joel K.
    Bunce, Richard A.
    MOLECULES, 2018, 23 (11):
  • [5] Synthesis and Antimicrobial Screening of Pyrazolo-3-Aryl Quinazolin-4(3H)ones
    Deshmukh, M. B.
    Patil, S.
    Patil, S. S.
    Jadhav, S. D.
    INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2010, 72 (04) : 500 - U104
  • [6] Green chemistry approach to the synthesis of 3-substituted-quinazolin-4(3H)-ones and 2-methyl-3-substituted-quinazolin-4(3H)-ones and biological evaluation
    Komar, Mario
    Molnar, Maja
    Jukic, Marijana
    Glavas-Obrovac, Ljubica
    Opacak-Bernardi, Teuta
    GREEN CHEMISTRY LETTERS AND REVIEWS, 2020, 13 (02) : 93 - 101
  • [7] Synthesis and Antimicrobial Activity of Novel 1,3,4-Oxadiazolyl-quinazolin-4(3H)ones
    Patel, Navin B.
    Patel, Jaymin C.
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2010, 47 (04) : 923 - 931
  • [8] Microwave-assisted synthesis of quinazolin-4(3H)-ones catalyzed by SbCl3
    Kang, Huaiyuan
    Wang, Weili
    Sun, Qinqiang
    Yang, Shuya
    Jin, Juan
    Zhang, Xuewen
    Ren, Xiaoliang
    Zhang, Jiming
    Zhou, Jianhua
    HETEROCYCLIC COMMUNICATIONS, 2018, 24 (06) : 293 - 296
  • [9] SYNTHESIS AND IN VITRO ANTIMICROBIAL EVALUATION OF PYRAZOLYL-QUINAZOLIN-4(3H)-ONES
    Patel, Navin B.
    Shaikh, Asif R.
    Barat, Gaman G.
    ACTA POLONIAE PHARMACEUTICA, 2012, 69 (06): : 1067 - 1075
  • [10] Microwave activated synthesis of 2-aryl-quinazolin-4(3H)ones
    M.Bakavoli
    O.Sabzevari
    M.Rahimizadeh
    ChineseChemicalLetters, 2007, (12) : 1466 - 1468
12345