Synthesis and Antimalarial Activity of Mallatojaponin C and Related Compounds

被引：13

作者：

Eaton, Alexander L. ^{[1
,2
]}

Dalal, Seema ^{[2
,3
]}

Cassera, M. Belen ^{[2
,3
]}

Zhao, Shugi ^{[1
,2
]}

Kingston, David G. I. ^{[1
,2
]}

机构：

[1] Virginia Tech, Dept Chem, Blacksburg, VA 24061 USA

[2] Virginia Tech, Ctr Drug Discovery, Blacksburg, VA 24061 USA

[3] Virginia Tech, Dept Biochem, Blacksburg, VA 24061 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2016年 / 79卷 / 06期

基金：

美国国家科学基金会;

关键词：

MALLOTUS-OPPOSITIFOLIUS; DIMERIC PHLOROGLUCINOLS; BIOMIMETIC SYNTHESIS; ACYLPHLOROGLUCINOLS;

D O I：

10.1021/acs.jnatprod.6b00347

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The phloroglucinol mallotojaponin C (1) from Mallotus oppositifolius, which was previously shown by us to have both antiplasmodial and cytocidal activities against the malaria parasite Plasmodium falciparum, was synthesized in three steps from 2',4',6'-trihydroxyacetophenone, and various derivatives were synthesized in an attempt to improve the bioactivity of this class of compounds. Two derivatives, the simple prenylated phloroglucinols 12 and 13, were found to have comparable antiplasmodial activities to that of mallotojaponin C.

引用

页码：1679 / 1683

页数：5

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