Varicella-zoster virus DNA in cells isolated from human trigeminal ganglia

被引：53

作者：

Levin, MJ

Cai, GY

Manchak, MD

Pizer, LI

机构：

[1] Univ Colorado, Hlth Sci Ctr, Sch Med, Sect Pediat Infect Dis, Denver, CO 80262 USA

[2] Univ Colorado, Dept Microbiol, Sch Med, Denver, CO 80262 USA

来源：

JOURNAL OF VIROLOGY | 2003年 / 77卷 / 12期

关键词：

D O I：

10.1128/JVI.77.12.6979-6987.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

To determine the type of cell(s) that contain latent varicella-zoster virus (VZV) DNA, we prepared pure populations of neurons and satellite cells from trigeminal ganglia of 18 humans who had previously had a VZV infection. VZV DNA was present in 34 of 2,226 neurons (1.5%) and in none of 20,700 satellite cells. There was an average of 4.7 (range of 2 to 9) copies of VZV DNA per latently infected neuron. Latent VZV DNA was primarily present in large neurons, whereas the size distribution of herpes simplex virus DNA was markedly different.

引用

收藏

页码：6979 / 6987

页数：9

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