Temperature-Sensitive Fluorescent Organic Nanoparticles with Aggregation-Induced Emission for Long-Term Cellular Tracing

被引：121
作者：
Wang, Zhen
Yong, Tu-Ying
Wan, Jiangshan
Li, Zi-He
Zhao, Hao
Zhao, Yanbing
Gan, Lu
Yang, Xiang-Liang
Xu, Hui-Bi
Zhang, Chun [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Wuhan 430074, Hubei, Peoples R China
来源：
ACS APPLIED MATERIALS & INTERFACES | 2015年 / 7卷 / 05期
基金：
中国国家自然科学基金;
关键词：
tetraphenylethene (TPE); poly(N-isoproylacryamide); (PNIPAM); fluorescent organic nanopartices; aggregation-induced emission (AIE); long-term celluar tracing; QUANTUM DOTS; TUNABLE EMISSION; IN-VIVO; NANOGELS; TRACKING; THERAPY; FABRICATION; MICELLES; DELIVERY; POLYMER;
D O I：
10.1021/am509161y
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Temperature-sensitive organic nanoparticles with AIE effect were assembled in water from tetraphenylethene-based poly(N-isopropylacrylamide) (TPE-PNIPAM), which was synthesized by ATRP using TPE derivative as initiator. The size and fluorescence of TPE-PNIPAM nanoparticles can be tuned by varying the temperature. These nanoparticles can be internalized readily by HeLa cells and can be used as long-term tracer in live cells to be retained for as long as seven passages.
引用
收藏
页码：3420 / 3425
页数：6
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