DNA vaccination with the human immunodeficiency virus type 1 SF162ΔV2 envelope elicits immune responses that offer partial protection from simian/human immunodeficiency virus infection to CD8+ T-cell-depleted rhesus macaques

被引：77

作者：

Cherpelis, S

Shrivastava, I

Gettie, A

Jin, X

Ho, DD

Barnett, SW

Stamatatos, L

机构：

[1] Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

[2] Chiron Corp, Emeryville, CA 94608 USA

[3] Tulane Reg Primate Res Ctr, Covington, LA 70433 USA

来源：

JOURNAL OF VIROLOGY | 2001年 / 75卷 / 03期

关键词：

D O I：

10.1128/JVI.75.3.1547-1550.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

DNA immunization of macaques with the SF162 Delta V2 envelope elicited lymphoproliferative responses and potent neutralizing antibodies. The animals were depleted of their CD8(+) T lymphocytes and then challenged intravenously with SHIV162P4. Compared to unvaccinated animals, the vaccinated macaques had lower peak viremia levels, rapidly cleared plasma virus, and showed delayed seroconversion.

引用

页码：1547 / 1550

页数：4

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