An efficient one-pot synthesis of N-(substituted phenyl)-1,2,5-thiadiazolidine-2-carboxamide 1,1-dioxide derivatives

被引：3

作者：

Hessainia, Sihem ^{[1
]}

Boukhari, Abbes ^{[1
]}

Cheraiet, Zinelaabidine ^{[2
]}

机构：

[1] Badji Mokhtar Annaba Univ, Dept Chem, Lab Organ Synth Modeling & Optimizat Chem Proc, POB 12, Annaba 23000, Algeria

[2] Ecole Super Technol Ind, Cite Saf Saf BP 21823000, Annaba, Algeria

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2020年 / 57卷 / 01期

关键词：

BIOLOGICAL EVALUATION; ANTITUMOR EVALUATION; INHIBITORS; SULFONYLUREAS;

D O I：

10.1002/jhet.3767

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1,2,5-Thiadiazolidine-1,1-dioxide carboxamide derivatives 3a-3n are novel heterocyclic compounds synthesized by multicomponent condensation reaction in one pot of aniline, chlorosulfonyl isocyanate, and 2-chloroethylamine hydrochloride which is used as a useful precursor under mild conditions. This reaction is realized with high atom economy, at room temperature and in a short reaction time. Series of these desired products are obtained from good to excellent yields within 2 hours in all cases. All the synthesized compounds are characterized by H-1, C-13 NMR, MS, and HMBC/HSQC spectroscopy.

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页码：218 / 224

页数：7

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