Microsatellite instability in adult T-cell leukaemia

被引：24
作者：
Hatta, Y
Yamada, Y
Tomonaga, M
Miyoshi, I
Said, JW
Koeffler, HP
机构：
[1] Univ Calif Los Angeles, Sch Med, Cedars Sinai Res Inst, Dept Med,Div Henatol Oncol, Los Angeles, CA 90048 USA
[2] Nagasaki Univ, Sch Med, Dept Lab Med & Haematol, Nagasaki 852, Japan
[3] Kochi Med Sch, Dept Internal Med, Kochi, Japan
[4] Univ Calif Los Angeles, Ctr Hlth Sci, Sch Med, Dept Pathol, Los Angeles, CA 90024 USA
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 1998年 / 101卷 / 02期
关键词：
adult T-cell leukaemia; mismatch repair; microsatellite instability; leukaemogenesis; replication error;
D O I：
10.1046/j.1365-2141.1998.00710.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Microsatellite instability (MSI) is thought to represent a defect of the DNA mismatch repair system which has been implicated in the tumourigenesis of several human malignancies. We investigated MSI in acute/lymphomatous adult T-cell leukaemia (ATL; n=22) using 54 highly polymorphic dinucleotide short-tandem repeat sequences. The corresponding control DNA from each individual was obtained from the peripheral blood in either chronic phase (n=5) or when complete remission was achieved (n=17). 10/22 (41%) patients had MSI, six of whom showed MST in multiple loci: four loci had MSL in multiple samples. The incidence of MST in ATL was found to be higher than in other haematological malignancies, indicating MSI as a feature of ATL, which may be involved in the progression of the disease.
引用
收藏
页码：341 / 344
页数：4
相关论文
共 12 条
[1]   MICROSATELLITE INSTABILITY IN PRIMARY NEOPLASMS FROM HIV+ PATIENTS [J].
BEDI, GC ;
WESTRA, WH ;
FARZADEGAN, H ;
PITHA, PM ;
SIDRANSKY, D .
NATURE MEDICINE, 1995, 1 (01) :65-68
[2]   Mutations and loss of expression of a mismatch repair gene, hMLH1, in leukemia and lymphoma cell lines [J].
Hangaishi, A ;
Ogawa, S ;
Mitani, K ;
Hosoya, N ;
Chiba, S ;
Yazaki, Y ;
Hirai, H .
BLOOD, 1997, 89 (05) :1740-1747
[3]   HOMOZYGOUS DELETIONS OF THE P15 (MTS2) AND P16 (CDKN2/MTS1) GENES IN ADULT T-CELL LEUKEMIA [J].
HATTA, Y ;
HIRAMA, T ;
MILLER, CW ;
YAMADA, Y ;
TOMONAGA, M ;
KOEFFLER, HP .
BLOOD, 1995, 85 (10) :2699-2704
[4]  
Hatta Y, 1997, INT J ONCOL, V11, P465
[5]   Absence of microsatellite instability during the progression of chronic myelocytic leukemia [J].
Mori, N ;
Takeuchi, S ;
Tasaka, T ;
Lee, S ;
Spira, S ;
BenYehuda, D ;
Mizoguchi, H ;
Schiller, G ;
Koeffler, HP .
LEUKEMIA, 1997, 11 (01) :151-152
[6]  
PELTOMAKI P, 1993, CANCER RES, V53, P5853
[7]   MSH2 DEFICIENT MICE ARE VIABLE AND SUSCEPTIBLE TO LYMPHOID TUMORS [J].
REITMAIR, AH ;
SCHMITS, R ;
EWEL, A ;
BAPAT, B ;
REDSTON, M ;
MITRI, A ;
WATERHOUSE, P ;
MITTRUCKER, HW ;
WAKEHAM, A ;
LIU, B ;
THOMASON, A ;
GRIESSER, H ;
GALLINGER, S ;
BALLHAUSEN, WG ;
FISHEL, R ;
MAK, TW .
NATURE GENETICS, 1995, 11 (01) :64-70
[8]  
ROBLEDO M, 1995, LEUKEMIA, V99, P60
[9]  
SAKASHITA A, 1992, BLOOD, V79, P477
[10]   Microsatellite instability and other molecular abnormalities in childhood acute lymphoblastic leukaemia [J].
Takeuchi, S ;
Seriu, T ;
Tasaka, T ;
Koike, M ;
Cho, SK ;
Park, S ;
Slater, J ;
Mufti, I ;
Hatta, Y ;
Miyoshi, I ;
Bartram, CR ;
Koeffler, HP .
BRITISH JOURNAL OF HAEMATOLOGY, 1997, 98 (01) :134-139
12