Impact of pharmacist intervention in patients with Alzheimer's disease

被引:1
|
作者
Forgerini, Marcela [1 ]
Lucchetta, Rosa Camila [2 ]
Oliveira, Fernanda Mariana [1 ]
Herdeiro, Maria Teresa [3 ]
Capela, Marisa Veiga [4 ]
Mastroianni, Patricia de Carvalho [1 ]
机构
[1] Sao Paulo State Univ, UNESP, Sch Pharmaceut Sci, Dept Drugs & Med, Araraquara, SP, Brazil
[2] Fed Univ Parana UFPR, Curitiba, Parana, Brazil
[3] Univ Aveiro, Inst Biomed iBiMED, Dept Med Sci, Aveiro, Portugal
[4] Sao Paulo State Univ, UNESP, Dept Phys & Chem, Araraquara, SP, Brazil
基金
巴西圣保罗研究基金会; 瑞典研究理事会;
关键词
Elderly; Face-to-face; Medication adherence; Medication errors; Medication review; COGNITIVE IMPAIRMENT; ELDERLY-PEOPLE; DRUG-THERAPY; OLDER-PEOPLE; DEPRESSION; ADHERENCE; DEMENTIA; RISK;
D O I
10.1590/s2175-97902022e19876
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
To assess the therapy relative to indication, effectiveness, safety and adherence in patients with Alzheimer's disease (AD). An interventional, prospective, non-randomized study was conducted in a single secondary care center in Brazil. The pharmacist-led Medication Therapy Management (MTM) was conducted to detect drug-related problems (DRPs) at baseline and after six months of intervention. The health status outcomes (i.e. cognitive screening tests; levels of glucose; total cholesterol; triglycerides; thyroid stimulating hormone; serum free thyroxine; and blood pressure) were measured. 66 patients with AD were included, of whom 55 patients completed the follow-up of six months. 36 patients (36/55) were non-adherent to AD drug therapy. Out of detected 166 DRPs, 116 were solved. Four patients were withdrawn from the AD protocol due to resolution of prodromal symptoms. On the conclusion of the study, the MTM improved and controlled blood pressure, glucose, total cholesterol and triglycerides levels (p<0.05). The pharmacist-led MTM was effective in solving 69.8% of DRPs, improving and controlling the clinical parameters evaluated.
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页数:13
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