Cycloartane-type triterpene glycosides anopanins A-C with monoacyldigalactosylglycerols from Anodendron paniculatum

被引：10

作者：

Viet Duc Ho ^{[1
]}

Thi Nhu Hanh Hoang ^{[2
]}

Quoc Hung Vo ^{[1
]}

Van Kiem Phan ^{[3
]}

Tuan Anh Le ^{[4
]}

Viet Ty Pham ^{[5
]}

Minh Hien Nguyen ^{[6
]}

Kodama, Takeshi ^{[6
]}

Ito, Takuya ^{[6
]}

Morita, Hiroyuki ^{[6
]}

Raal, Ain ^{[7
]}

Thi Hoai Nguyen ^{[1
]}

机构：

[1] Hue Univ, Hue Univ Med & Pharm, Fac Pharm, 06 Ngo Quyen, Hue City, Vietnam

[2] Hue Univ, Fac Chem, Coll Sci, 77 Nguyen Hue, Hue City, Vietnam

[3] VAST, Inst Marine Biochem, 18 Hoang Quoc Viet, Hanoi, Vietnam

[4] VAST, Mientrung Inst Sci Res, Quang Tri Ctr Sci & Technol, Dong Ha, Quang Tri, Vietnam

[5] Hue Univ, Hue Univ Educ, Fac Chem, 34 Le Loi, Hue City, Vietnam

[6] Univ Toyama, Inst Nat Med, 2630 Sugitani, Toyama 9300194, Japan

[7] Univ Tartu, Inst Pharm, 1 Nooruse Str, EE-50411 Tartu, Estonia

来源：

PHYTOCHEMISTRY | 2017年 / 144卷

基金：

日本学术振兴会;

关键词：

Anodendron paniculatum; Apocynaceae; Cycloartane-type triterpene glycosides; Anopanins A-C; Anticancer activity; SAPONINS; PHYTOECDYSTEROIDS; LEAVES; ROOTS;

D O I：

10.1016/j.phytochem.2017.09.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three cycloartane-type triterpene glycosides (anopanins A-C), together with three known monoacyldigalactosylglycerols gingerglycolipids A-C and (2S)-1-O-palmitoyl-3-O-[alpha-D-galactopyranosyl-(1 -> 6)-beta-D-galactopyranosyl]-sn-glycerol, were isolated from the aerial parts of Anodendron paniculatum collected in Viet Nam. The chemical structures of the present compounds were elucidated by means of 1D and 2D NMR and HRESIMS spectroscopy, and by comparing to the reported data in the literature. These compounds did not show significant growth inhibitory activities (IC50 > 100 mu g/mL) against the tested cancer cell lines LU-1 (lung adenocarcinoma), KB (epidermoid carcinoma), Hep-G2 (hepatoma cancer), MKN-7 (stomach cancer), and SW-480 (colon adenocarcinoma). (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：113 / 118

页数：6

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