[Ag(PcL)]-Catalyzed Domino Reactions of 2-Alkynylbenzaldehydes with Electron-Poor Anilines: Synthesis of 1-Aminoisochromenes

被引：11

作者：

Pirovano, Valentina ^{[1
]}

Hamdan, Gabriele ^{[1
]}

Garanzini, Davide ^{[1
]}

Brambilla, Elisa ^{[1
]}

Rossi, Elisabetta ^{[1
]}

Caselli, Alessandro ^{[2
,3
]}

Abbiati, Giorgio ^{[1
]}

机构：

[1] Univ Milan, Sez Chim Gen & Organ A Marchesini, Dipartimento Sci Farmaceut, Via Venezian 21, I-20133 Milan, Italy

[2] Univ Milan, Dipartimento Chim, Via Golgi 19, I-20133 Milan, Italy

[3] CNR, SCITEC, Via Golgi 19, I-20133 Milan, Italy

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 2020卷 / 17期

关键词：

Isochromenes; Alkynes; Domino reactions; Silver; Electron-poor anilines; Macrocyclic ligands; CYCLIC ALKENYL ETHERS; O-ALKYNYLBENZALDEHYDES; LEWIS-ACID; CYCLIZATION; HETEROCYCLES; ALKYNES; SILVER; ISOQUINOLINES; DERIVATIVES; CATALYST;

D O I：

10.1002/ejoc.202000275

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this paper, we describe the synthesis of neglected 1-aminoisochromene derivatives starting from 2-alkynylbenzaldehydes and electron-poor anilines. The domino reaction is catalyzed by original [(AgPcL)-Pc-I] complexes and occurs with complete regioselectivity under mild conditions. The approach well-tolerates different aryl, heteroaryl, alkyl and cycloalkyl substituents on alkyne terminus to give the desired products in modest to very good yields.

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页码：2592 / 2599

页数：8

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