Genetic and environmental modulation of neurodevelopmental disorders: Translational insights from labs to beds

被引：39
作者：
Homberg, Judith R. [1 ]
Kyzar, Evan J. [2 ,3 ,4 ]
Scattoni, Maria Luisa [5 ]
Norton, William H. [6 ]
Pittman, Julian [7 ]
Gaikwad, Siddharth [3 ,4 ]
Nguyen, Michael [3 ,4 ,8 ]
Poudel, Manoj K. [3 ,4 ]
Ullmann, Jeremy F. P. [9 ,10 ,11 ]
Diamond, David M. [12 ,13 ]
Kaluyeva, Aleksandra A. [3 ,4 ]
Parker, Matthew O. [14 ]
Brown, Richard E. [15 ]
Song, Cai [16 ,17 ]
Gainetdinov, Raul R. [18 ,19 ]
Gottesman, Irving I. [20 ]
Kalueff, Allan V. [18 ]
机构：
[1] Radboud Univ Nijmegen, Dept Cognit Neurosci, Donders Inst Brain Cognit & Behav, Med Ctr, Nijmegen, Netherlands
[2] Univ Illinois, Dept Psychiat, Coll Med, Chicago, IL 60612 USA
[3] Int Stress & Behav Soc, Slidell, LA USA
[4] ZENEREI Res Ctr, Slidell, LA USA
[5] Ist Super Sanita, Dept Cell Biol & Neurosci, Rome, Italy
[6] Univ Leicester, Dept Biol, Leicester, Leics, England
[7] Troy Univ, Dept Biol & Environm Sci, Troy, AL USA
[8] NYU, Sch Med, New York, NY 10003 USA
[9] Univ Queensland, Ctr Adv Imaging, Brisbane, Qld, Australia
[10] Boston Childrens Hosp, Dept Neurol, Boston, MA USA
[11] Harvard Med Sch, Dept Neurol, Boston, MA USA
[12] Univ S Florida, Dept Psychol, Tampa, FL USA
[13] JA Haley Vet Hosp, Res & Dev Serv, Tampa, FL USA
[14] Univ Portsmouth, Sch Hlth Sci & Social Work, Portsmouth, Hants, England
[15] Dalhousie Univ, Dept Psychol & Neurosci, Halifax, NS, Canada
[16] Guangdong Ocean Univ, Res Inst Marine Drugs & Nutr, Coll Food Sci & Technol, Zhanjiang, Guangdong, Peoples R China
[17] China Med Univ Hosp, Grad Inst Neural & Cognit Sci, Taichung, Taiwan
[18] St Petersburg State Univ, Inst Translat Biomed, St Petersburg, Russia
[19] Skolkovo Inst Sci & Technol, Skolkovo, Moscow Region, Russia
[20] Univ Minnesota, Dept Psychol, Minneapolis, MN USA
来源：
BRAIN RESEARCH BULLETIN | 2016年 / 125卷
基金：
俄罗斯科学基金会;
关键词：
Neurodevelopmental disorder; Model organism; Experimental model; Preclinical study; Translational research; POSTTRAUMATIC-STRESS-DISORDER; AUTISM SPECTRUM DISORDER; FRAGILE-X-SYNDROME; DE-NOVO MUTATIONS; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; POSTSYNAPTIC DENSITY PROTEINS; SEROTONIN REUPTAKE INHIBITORS; TUBEROUS SCLEROSIS COMPLEX; MINOR PHYSICAL ANOMALIES; CPG-BINDING PROTEIN-2;
D O I：
10.1016/j.brainresbull.2016.04.015
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Neurodevelopmental disorders (NDDs) are a heterogeneous group of prevalent neuropsychiatric illnesses with various degrees of social, cognitive, motor, language and affective deficits. NDDs are caused by aberrant brain development due to genetic and environmental perturbations. Common NDDs include autism spectrum disorder (ASD), intellectual disability, communication/speech disorders, motor/tic disorders and attention deficit hyperactivity disorder. Genetic and epigenetic/environmental factors play a key role in these NDDs with significant societal impact. Given the lack of their efficient therapies, it is important to gain further translational insights into the pathobiology of NDDs. To address these challenges, the International Stress and Behavior Society (ISBS) has established the Strategic Task Force on NDDs. Summarizing the Panel's findings, here we discuss the neurobiological mechanisms of selected common NDDs and a wider NDD+ spectrum of associated neuropsychiatric disorders with developmental trajectories. We also outline the utility of existing preclinical (animal) models for building translational and cross-diagnostic bridges to improve our understanding of various NDDs. (C) 2016 Elsevier Inc. All rights reserved.
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页码：79 / 91
页数：13
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