An azine-based carbothioamide chemosensor for selective and sensitive turn-on-off sequential detection of Zn(II) and H2PO4, live cell imaging and INHIBIT logic gate

被引：33

作者：

Purkait, Rakesh ^{[1
]}

Das Mahapatra, Ananya ^{[2
,3
]}

Chattopadhyay, Debprasad ^{[2
,3
]}

Sinha, Chittaranjan ^{[1
]}

机构：

[1] Jadavpur Univ, Dept Chem, Kolkata 700032, India

[2] ICMR Virus Unit, Infect Dis, GB-4,57,SC Bannerjee Rd, Kolkata 700010, India

[3] Beliaghata Gen Hosp, GB-4,57,SC Bannerjee Rd, Kolkata 700010, India

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2019年 / 207卷

关键词：

Hydrazino-carbothioamide sensor; Turn-on-off detection; Zn(II) and H2PO4-; INHIBIT logic gate; Live cell imaging; FLUORESCENCE SENSOR; BINDING DOMAINS; ZN2+; ZINC; PROBE; DENSITY; AL3+; PHOSPHORYLATION; MOLECULES; IONS;

D O I：

10.1016/j.saa.2018.09.019

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

Hydrazino-carbothioamide, 1, serves as a turn-on fluorescent chemosensor to Zn2+ and the mixture shows green emission (lambda(em) 492) in presence of large number of ions with impressive limit of detection (LOD), 0.59 nM. Intense fluorescence of Zn-complex is selectively turn-off upon adding H2PO4- only to the limit of detection, 26.IM, while other anions remain silent. The sensing mechanism of 1 is established by suppressing the ESIPT of 1 and complexation with Zn2+ (CHEF) is supported by Job's plot, H-1 NMR, and HR-MS data. Turn-on-off sequential detection of Zn2+ and H2PO4- also have successfully been employed for the engineering of INHIBIT molecular logic gate. The sensor is non-toxic and has been used in identifying Zn2+ in the intracellular region of African green monkey kidney cells (Vero cells). (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：164 / 172

页数：9

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