Rational dosing of azathioprine and 6-mercaptopurine

被引：114
作者：
Sandborn, WJ [1 ]
机构：
[1] Mayo Clin & Mayo Fdn, Div Gastroenterol & Hepatol, Inflammatory Bowel Dis Clin, Rochester, MN 55905 USA
来源：
GUT | 2001年 / 48卷 / 05期
关键词：
D O I：
10.1136/gut.48.5.591
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
引用
收藏
页码：591 / 592
页数：2
相关论文
共 13 条
[1]   Thiopurine methyltransferase genotype predicts therapy-limiting severe toxicity from azathioprine [J].
Black, AJ ;
McLeod, HL ;
Capell, HA ;
Powrie, RH ;
Matowe, LK ;
Pritchard, SC ;
Collie-Duguid, ESR ;
Reid, DM .
ANNALS OF INTERNAL MEDICINE, 1998, 129 (09) :716-718
[2]   Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy [J].
Colombel, JF ;
Ferrari, N ;
Debuysere, H ;
Marteau, P ;
Gendre, JP ;
Bonaz, B ;
Soulé, JC ;
Modgliani, R ;
Touze, Y ;
Catala, P ;
Libersa, C ;
Broly, F .
GASTROENTEROLOGY, 2000, 118 (06) :1025-1030
[3]   Utilisation of erythrocyte 6-thioguanine metabolite levels to optimise azathioprine therapy in patients with inflammatory bowel disease [J].
Cuffari, C ;
Hunt, S ;
Bayless, T .
GUT, 2001, 48 (05) :642-646
[4]   6-Mercaptopurine metabolism in Crohn's disease: Correlation with efficacy and toxicity [J].
Cuffari, C ;
Theoret, Y ;
Latour, S ;
Seidman, G .
GUT, 1996, 39 (03) :401-406
[5]   Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease [J].
Dubinsky, MC ;
Lamothe, S ;
Yang, HY ;
Targan, SR ;
Sinnett, D ;
Théorêt, Y ;
Seidman, EG .
GASTROENTEROLOGY, 2000, 118 (04) :705-713
[6]   Thioguanine (6-TG): A therapeutic alternative in a subgroup of IBD patients failing 6-mercaptopurine (6-MP) [J].
Dubinsky, MC ;
Hassard, PV ;
Abreu, MT ;
Kam, LY ;
Seidman, EG ;
Targan, SR ;
Vasiliauskas, EA .
GASTROENTEROLOGY, 2000, 118 (04) :A891-A891
[7]   6-mercaptopurine (6MP) metabolite levels in children with IBD: Lack of correlation of 6-thioguanine (6TG) levels with clinical response. [J].
Gupta, P ;
Gokhale, R ;
Kirschner, BS .
GASTROENTEROLOGY, 2000, 118 (04) :A787-A787
[8]   THE CLINICAL-PHARMACOLOGY OF 6-MERCAPTOPURINE [J].
LENNARD, L .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1992, 43 (04) :329-339
[9]   Cross-sectional study of ibd patients taking azathioprine (AZA) or 6 mercaptopurine (6-MP): Lack of correlation between disease activity and 6 thioguanine nucleotide (6TGN) concentration. [J].
Lowry, PW ;
Franklin, CL ;
Weaver, AL ;
Pike, MG ;
Mays, DC ;
Tremaine, WJ ;
Lipsky, JJ ;
Sandborn, WJ .
GASTROENTEROLOGY, 2000, 118 (04) :A788-A788
[10]   AZATHIOPRINE AND 6-MERCAPTOPURINE IN CROHN DISEASE - A METAANALYSIS [J].
PEARSON, DC ;
MAY, GR ;
FICK, GH ;
SUTHERLAND, LR .
ANNALS OF INTERNAL MEDICINE, 1995, 123 (02) :132-142
12