Structure-activity relationship of N-methyl-bisindolylmaleimide derivatives as cell death inhibitors

被引：25

作者：

Katoh, M

Dodo, K

Fujita, M

Sodeoka, M

机构：

[1] Tohoku Univ, IMRAM, Sendai, Miyagi 9808577, Japan

[2] Sagami Chem Res Ctr, Kanagawa, Japan

[3] RIKEN, Inst Phys & Chem Res, Wako, Saitama 3510198, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 12期

基金：

日本学术振兴会;

关键词：

cell death; necrosis; apoptosis; bisindolylmaleimide;

D O I：

10.1016/j.bmcl.2005.04.015

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of N-methyl-bisindolylmaleimide derivatives was synthesized and evaluated as cell death inhibitors. N-Methyl-2[1-(3-aminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide (21) was the most potent inhibitor of H2O2-induced necrotic death of human leukemia HL60 cells among them. (c) 2005 Elsevier Ltd. All rights reserved.

引用

收藏

页码：3109 / 3113

页数：5

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