Amyloid beta peptides electrochemistry: A review

被引：13
|
作者：
Chiorcea-Paquim, Ana-Maria [1 ,2 ]
Oliveira-Brett, Ana Maria [1 ,2 ]
机构：
[1] Univ Coimbra, Ctr Mech Engn Mat & Proc CEMMPRE, Dept Chem, P-3004535 Coimbra, Portugal
[2] Inst Pedro Nunes, P-3030199 Coimbra, Portugal
来源：
CURRENT OPINION IN ELECTROCHEMISTRY | 2022年 / 31卷
关键词：
Alzheimer's disease (AD); Amyloid beta (A beta); Fibrilization; Aggregation; Adsorption; Oxidation; Voltammetry; AD biomarker; BORON-DOPED DIAMOND; ALZHEIMER A-BETA; CARBON ELECTRODES; COPPER-COMPLEXES; REDOX PROPERTIES; AGGREGATION; OXIDATION; TYROSINE; DISEASE; BINDING;
D O I：
10.1016/j.coelec.2021.100837
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Alzheimer disease is a progressive age-related neurodegenerative disorder estimated to affect up to 107 million people by 2050, its pathology is associated with the dysfunction of the amyloid beta (A beta) peptide mechanism, among others. Electrochemical methods were successfully applied for A beta electrochemical characterisation and have received increased attention in Ab research. This review discusses the recent advances on the direct electrochemical detection of A beta redox mechanisms, fibrilization and interaction with metal ions based on the electrochemical detection of the A beta's Y, H and M amino acid residues oxidation peaks.
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页数：10
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