Combined detection of miR-21-5p, miR-30a-3p, miR-30a-5p, miR-155-5p, miR-216a and miR-217 for screening of early heart failure diseases

被引：36
|
作者：
Ding, Han [1 ]
Wang, Yin [1 ]
Hu, Longgang [2 ]
Xue, Sheng [1 ]
Wang, Yu [1 ]
Zhang, Lei [1 ]
Zhang, Yuan [1 ]
Qi, Hongzhao [1 ]
Yu, Hua [2 ]
Aung, Lynn Htet Htet [1 ]
An, Yi [2 ]
Li, Peifeng [1 ]
机构：
[1] Qingdao Univ, Med Coll, Inst Translat Med, Qingdao 266071, Peoples R China
[2] Qingdao Univ, Affiliated Cardiovasc Hosp, Qng Dao 266071, Peoples R China
来源：
BIOSCIENCE REPORTS | 2020年 / 40卷
基金：
中国国家自然科学基金;
关键词：
CIRCULATING MICRORNAS; GENES; FETAL; PCR;
D O I：
10.1042/BSR20191653
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The use of circulating microRNAs as biomarkers opens up new opportunities for the diagnosis of cardiovascular diseases because of their specific expression profiles. The aim of the present study was to identify circulating microRNAs in human plasma as potential biomarkers of heart failure and related diseases. We used real-time quantitative PCR to screen microRNA in plasma samples from 62 normal controls and 62 heart failure samples. We found that circulating miR-21-5p, miR-30a-3p, miR-30a-5p, miR-155-5p, miR-216a and miR-217 expressed differently between healthy controls and heart failure patients. Plasma levels of miR-21-5p, miR-30a-3p, miR-30a-5p, miR-155-5p, miR-216a and miR-217 were unaffected by hemolysis. Correlation analysis showed any two of these miRNAs possess a strong correlation, indicating a possibility of combined analysis. MiR-21-5p, miR-30a-3p, miR-30a-5p, miR-155-5p, miR-216a and miR-217 could be combined in two or three or more combinations. The results suggest that miR-21-5p, miR-30a-3p, miR-30a-5p, miR-155-5p, miR-216a and miR-217 may be a new diagnostic biomarker for heart failure and related diseases.
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页数：8
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