Fatty acids in breast milk and development of atopic eczema and allergic sensitisation in infancy

被引:82
作者
Thijs, C. [1 ,2 ]
Mueller, A. [3 ]
Rist, L. [4 ]
Kummeling, I.
Snijders, B. E. P.
Huber, M. [5 ]
van Ree, R. [6 ,7 ]
Simoes-Wuest, A. P. [4 ]
Dagnelie, P. C.
van den Brandt, P. A.
机构
[1] Maastricht Univ, Dept Epidemiol, CAPHRI Sch Publ Hlth & Primary Care, NL-6200 MD Maastricht, Netherlands
[2] Maastricht Univ, NUTRIM Sch Nutr Toxicol & Metab, Maastricht, Netherlands
[3] Univ Hamburg, Dept Food Chem, Hamburg, Germany
[4] Paracelsus Hosp Richterswil, Richterswil, Switzerland
[5] Louis Bolk Inst, Driebergen, Netherlands
[6] Univ Amsterdam, Acad Med Ctr, Dept Expt Immunol, NL-1105 AZ Amsterdam, Netherlands
[7] Sanquin, Dept Immunopathol, Amsterdam, Netherlands
关键词
atopy; eczema; human milk; omega-3 fatty acids; organic dairy; ruminant fatty acids; CONJUGATED LINOLEIC-ACID; LACTATING WOMEN; BIRTH COHORT; PRESCHOOL-CHILDREN; CHILDHOOD ASTHMA; FISH CONSUMPTION; DIETARY-FAT; PREGNANCY; DISEASE; RISK;
D O I
10.1111/j.1398-9995.2010.02445.x
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
P>Background: One of the explanations for the increasing prevalence of atopic diseases is a relative low perinatal supply of n-3 fatty acids. However, this does not explain the protective effects of whole-fat dairy products or high levels of transfatty acids in breast milk, observed in some studies. We evaluated the role of perinatal supply of fatty acids in the early development of atopic eczema and allergic sensitisation. Methods: Fatty acids, including n-3 long-chain polyunsaturated fatty acids (LCPs) as well as ruminant fatty acids (rumenic acid, cis-9,trans-11-C18:2 conjugated linoleic acid; and vaccenic acid, trans-11-C18:1), were determined in breast milk sampled at 1 month postpartum from 310 mother-infant pairs in the KOALA Birth Cohort Study, the Netherlands. Children were followed for atopic outcomes until 2 years of age. Results: Higher concentrations of n-3 LCPs as well as ruminant fatty acids were associated with lower risk of (1) parent-reported eczema, (2) atopic dermatitis (UK Working Party criteria), and (3) sensitisation at age 1 year (as revealed by specific serum IgE levels to cow's milk, hen's egg and/or peanut). In multivariable logistic regression analysis, the inverse associations between ruminant fatty acid concentrations in breast milk and atopic outcomes were found to be independent from n-3 LCPs. Conclusions: The results confirm a protective role of preformed n-3 LCPs in the development of atopic disease. Moreover, this is the first study in humans confirming results from animal studies of protective effects of ruminant fatty acids against the development of atopic manifestations.
引用
收藏
页码:58 / 67
页数:10
相关论文
共 37 条
[1]   IMMUNOGLOBULIN-E ANTIBODIES THAT CROSSREACT WITH VEGETABLE FOODS, POLLEN, AND HYMENOPTERA VENOM [J].
AALBERSE, RC ;
KOSHTE, V ;
CLEMENS, JGJ .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1981, 68 (05) :356-364
[2]   Biological effects of conjugated linoleic acids in health and disease [J].
Bhattacharya, Arunabh ;
Banu, Jameela ;
Rahman, Mizanur ;
Causey, Jennifer ;
Fernandes, Gabriel .
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2006, 17 (12) :789-810
[3]   Dietary fat and asthma: Is there a connection? [J].
Black, PN ;
Sharpe, S .
EUROPEAN RESPIRATORY JOURNAL, 1997, 10 (01) :6-12
[4]   Margarine consumption and allergy in children [J].
Bolte, G ;
Frye, C ;
Hoelscher, B ;
Meyer, I ;
Wjst, M ;
Heinrich, J .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2001, 163 (01) :277-279
[5]   Consumption of fish, butter and margarine during pregnancy and development of allergic sensitizations in the offspring:: role of maternal atopy [J].
Calvani, M ;
Alessandri, C ;
Sopo, SM ;
Panetta, V ;
Pingitore, G ;
Tripodi, S ;
Zappalà, D ;
Zicari, AM .
PEDIATRIC ALLERGY AND IMMUNOLOGY, 2006, 17 (02) :94-102
[6]   Protective effect of fruits, vegetables and the Mediterranean diet on asthma and allergies among children in [J].
Chatzi, Leda ;
Apostolaki, Gianna ;
Bibakis, Ioannis ;
Skypala, Isabel ;
Bibaki-Liakou, Vasilki ;
Tzanakis, Nikolaos ;
Kogevinas, Manolis ;
Cullinan, Paul .
THORAX, 2007, 62 (08) :677-683
[7]   Diet, serum fatty acids, and atopic diseases in childhood [J].
Dunder, T ;
Kuikka, L ;
Turtinen, J ;
Räsänen, L ;
Uhari, M .
ALLERGY, 2001, 56 (05) :425-428
[8]  
ISAAC. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee, 1998, LANCET, V351, P1225
[9]   Cis-9,trans-11-conjugated linoleic acid inhibits allergic sensitization and airway inflammation via a PPARγ-related mechanism in mice [J].
Jaudszus, Anke ;
Krokowski, Martin ;
Moeckel, Peter ;
Darcan, Yasemin ;
Avagyan, Anzhela ;
Matricardi, Paolo ;
Jahreis, Gerhard ;
Hamelmann, Eckard .
JOURNAL OF NUTRITION, 2008, 138 (07) :1336-1342
[10]   Bovine milk fat enriched in conjugated linoleic and vaccenic acids attenuates allergic airway disease in mice [J].
Kanwar, R. K. ;
MacGibbon, A. K. ;
Black, P. N. ;
Kanwar, J. R. ;
Rowan, A. ;
Vale, M. ;
Krissansen, G. W. .
CLINICAL AND EXPERIMENTAL ALLERGY, 2008, 38 (01) :208-218