Surface analyses and immune reactivities of major cell wall-associated proteins of group A streptococcus

被引:87
作者
Cole, JN
Ramirez, RD
Currie, BJ
Cordwell, SJ
Djordjevic, SP
Walker, MJ [1 ]
机构
[1] Univ Wollongong, Sch Biol Sci, Wollongong, NSW 2522, Australia
[2] Charles Darwin Univ, Menzies Sch Hlth Res, Darwin, NT, Australia
[3] Macquarie Univ, Australian Proteome Anal Facil, Sydney, NSW 2109, Australia
[4] NSW Agr, Elizabeth Macarthur Agr Inst, Camden, NSW, Australia
关键词
D O I
10.1128/IAI.73.5.3137-3146.2005
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
A proteomic analysis was undertaken to identify cell wall-associated proteins of Streptococcus pyogenes. Seventy-four distinct cell wall-associated proteins were identified, 66 of which were novel. Thirty-three proteins were immunoreactive with pooled S. pyogenes-reactive human antisera. Biotinylation of the GAS cell surface identified 23 cell wall-associated proteins that are surface exposed.
引用
收藏
页码:3137 / 3146
页数:10
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