Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies

被引：723
作者：
Bernardi, Rosa [1 ]
Pandolfi, Pier Paolo [1 ]
机构：
[1] Beth Israel Deaconess Med Ctr, Beth Israel Deaconess Canc Ctr, Harvard Med Sch, Dept Med,Canc Genet Program, Boston, MA 02215 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2007年 / 8卷 / 12期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nrm2277
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The promyelocytic leukaemia (PML) tumour suppressor protein epitomizes the PML-nuclear body (PML-NB) and is crucially required for the proper assembly of this macromolecular nuclear structure. Unlike other, more specialized subnuclear structures such as Cajal and Polycomb group bodies, PML-NBs are functionally promiscuous and have been implicated in the regulation of diverse cellular functions. PML-NBs are dynamic structures that favour the sequestration and release of proteins, mediate their post-translational modifications and promote specific nuclear events in response to various cellular stresses. Recent data suggest that PML-NBs may be heterogeneous in composition, mobility and function.
引用
收藏
页码：1006 / 1016
页数：11
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