Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies

被引：723
作者：
Bernardi, Rosa [1 ]
Pandolfi, Pier Paolo [1 ]
机构：
[1] Beth Israel Deaconess Med Ctr, Beth Israel Deaconess Canc Ctr, Harvard Med Sch, Dept Med,Canc Genet Program, Boston, MA 02215 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2007年 / 8卷 / 12期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nrm2277
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The promyelocytic leukaemia (PML) tumour suppressor protein epitomizes the PML-nuclear body (PML-NB) and is crucially required for the proper assembly of this macromolecular nuclear structure. Unlike other, more specialized subnuclear structures such as Cajal and Polycomb group bodies, PML-NBs are functionally promiscuous and have been implicated in the regulation of diverse cellular functions. PML-NBs are dynamic structures that favour the sequestration and release of proteins, mediate their post-translational modifications and promote specific nuclear events in response to various cellular stresses. Recent data suggest that PML-NBs may be heterogeneous in composition, mobility and function.
引用
收藏
页码：1006 / 1016
页数：11
相关论文
共 124 条
  • [11] Deconstructing PML-induced premature senescence
    Bischof, O
    Kirsh, O
    Pearson, M
    Itahana, K
    Pelicci, PG
    Dejean, A
    [J]. EMBO JOURNAL, 2002, 21 (13) : 3358 - 3369
  • [12] Promyelocytic leukemia nuclear bodies are predetermined processing sites for damaged DNA
    Boe, Stig Ove
    Haave, Marte
    Jul-Larsen, Asne
    Grudic, Amra
    Bjerkvig, Rolf
    Lonning, Per Eystein
    [J]. JOURNAL OF CELL SCIENCE, 2006, 119 (16) : 3284 - 3295
  • [13] Promyelocytic leukemia (PML) nuclear bodies are protein structures that do not accumulate RNA
    Boisvert, FM
    Hendzel, MJ
    Bazett-Jones, DP
    [J]. JOURNAL OF CELL BIOLOGY, 2000, 148 (02) : 283 - 292
  • [14] Pondering the promyelocytic leukemia protein (PML) puzzle: Possible functions for PML nuclear bodies
    Borden, KLB
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (15) : 5259 - 5269
  • [15] The PML gene is not involved in the regulation of MHC class I expression in human cell lines
    Bruno, S
    Ghiotto, F
    Fais, F
    Fagioli, M
    Luzi, L
    Pelicci, PG
    Grossi, CE
    Ciccone, E
    [J]. BLOOD, 2003, 101 (09) : 3514 - 3519
  • [16] PML4 induces differentiation by Myc destabilization
    Buschbeck, M.
    Uribesalgo, I.
    Ledl, A.
    Gutierrez, A.
    Minucci, S.
    Muller, S.
    Di Croce, L.
    [J]. ONCOGENE, 2007, 26 (23) : 3415 - 3422
  • [17] Promyelocytic leukemia (PML) nuclear bodies are disorganized in colorectal tumors with total loss of major histocompatibility complex class I expression and LMP7 downregulation
    Cabrera, CM
    Jiménez, P
    Concha, A
    Garrido, F
    Ruiz-Cabello, F
    [J]. TISSUE ANTIGENS, 2004, 63 (05): : 446 - 452
  • [18] PML NBs associate with the hMre11 complex and p53 at sites of irradiation induced DNA damage
    Carbone, R
    Pearson, M
    Minucci, S
    Pelicci, PG
    [J]. ONCOGENE, 2002, 21 (11) : 1633 - 1640
  • [19] THE PML GENE ENCODES A PHOSPHOPROTEIN ASSOCIATED WITH THE NUCLEAR MATRIX
    CHANG, KS
    FAN, YH
    ANDREEFF, M
    LIU, JX
    MU, ZM
    [J]. BLOOD, 1995, 85 (12) : 3646 - 3653
  • [20] Chang SK, 2002, MOL CELLS, V14, P130
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