Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies

被引：725

作者：

Bernardi, Rosa ^{[1
]}

Pandolfi, Pier Paolo ^{[1
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Beth Israel Deaconess Canc Ctr, Harvard Med Sch, Dept Med,Canc Genet Program, Boston, MA 02215 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2007年 / 8卷 / 12期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm2277

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The promyelocytic leukaemia (PML) tumour suppressor protein epitomizes the PML-nuclear body (PML-NB) and is crucially required for the proper assembly of this macromolecular nuclear structure. Unlike other, more specialized subnuclear structures such as Cajal and Polycomb group bodies, PML-NBs are functionally promiscuous and have been implicated in the regulation of diverse cellular functions. PML-NBs are dynamic structures that favour the sequestration and release of proteins, mediate their post-translational modifications and promote specific nuclear events in response to various cellular stresses. Recent data suggest that PML-NBs may be heterogeneous in composition, mobility and function.

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页码：1006 / 1016

页数：11

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