The Transcriptional Coregulators TIF2 and SRC-1 Regulate Energy Homeostasis by Modulating Mitochondrial Respiration in Skeletal Muscles

被引：62
作者：
Duteil, Delphine [1 ,2 ,3 ]
Chambon, Celine [1 ,2 ,3 ]
Ali, Faisal [1 ,2 ,3 ]
Malivindi, Rocco [1 ]
Zoll, Joffrey [4 ,6 ,7 ]
Kato, Shigeaki [8 ]
Geny, Bernard [4 ,6 ,7 ]
Chambon, Pierre [1 ,2 ,3 ,5 ]
Metzger, Daniel [1 ,2 ,3 ]
机构：
[1] IGBMC, Dept Physiol Genet, F-67404 Illkirch Graffenstaden, France
[2] INSERM, U964, F-67404 Illkirch Graffenstaden, France
[3] CNRS, UMR7104, F-67404 Illkirch Graffenstaden, France
[4] Univ Strasbourg, Dept Physiol, F-67000 Strasbourg, France
[5] Coll France, F-67404 Illkirch Graffenstaden, France
[6] Univ Strasbourg, EA 3072, Fac Med, F-67000 Strasbourg, France
[7] CHRU, Serv Physiol & Explorat Fonct, F-67091 Strasbourg, France
[8] Univ Tokyo, Inst Mol & Cellular Biosci, Tokyo 1130032, Japan
来源：
CELL METABOLISM | 2010年 / 12卷 / 05期
关键词：
HUMAN UNCOUPLING PROTEIN-3; FATTY-ACID OXIDATION; DIET-INDUCED OBESITY; TRANSGENIC MICE; FIBER-TYPE; COACTIVATOR PGC-1; CELLULAR-ENERGY; THYROID-HORMONE; PGC-1-ALPHA; EXPRESSION;
D O I：
10.1016/j.cmet.2010.09.016
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The two p160 transcriptional coregulator family members SRC-1 and TIF2 have important metabolic functions in white and brown adipose tissues as well as in the liver. To analyze TIF2 cell-autonomous functions in skeletal muscles, we generated TIF2((i)skm-/-) mice in which TIF2 was selectively ablated in skeletal muscle myofibers at adulthood. We found that increased mitochondrial uncoupling in skeletal muscle myocytes protected these mice from decreased muscle oxidative capacities induced by sedentariness, delayed the development of type 2 diabetes, and attenuated high-caloric-diet-induced obesity. Moreover, our results demonstrate that SRC-1 and TIF2 can modulate the expression of the uncoupling protein 3 (UCP3) in an antagonistic manner and that enhanced SRC-1 levels in TIF2-deficient myofibers are critically involved in the metabolic changes of TIF2((1)skm-/-) mice. Thus, modulation of the expression and/or activity of these coregulators represents an attractive way to prevent or treat metabolic disorders.
引用
收藏
页码：496 / 508
页数：13
相关论文
共 46 条
  • [1] Cloning and characterization of the 5′ flanking region of the human uncoupling protein 3 (UCP3) gene
    Acín, A
    Rodriguez, M
    Rique, H
    Canet, E
    Boutin, JA
    Galizzi, JP
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 258 (02) : 278 - 283
  • [2] A HISTOCHEMICAL AND MORPHOLOGICAL-STUDY OF SKELETAL-MUSCLE FROM OBESE HYPERGLYCEMIC OB/OB MICE
    ALMOND, RE
    ENSER, M
    [J]. DIABETOLOGIA, 1984, 27 (03) : 407 - 413
  • [3] PGC-1 coactivators and skeletal muscle adaptations in health and disease
    Arany, Zolt
    [J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 2008, 18 (05) : 426 - 434
  • [4] Caloric restriction reduces fiber loss and mitochondrial abnormalities in aged rat muscle
    Aspnes, LE
    Lee, CM
    Weindruch, R
    Chung, SS
    Roecker, EB
    Aiken, JM
    [J]. FASEB JOURNAL, 1997, 11 (07) : 573 - 581
  • [5] No decline in skeletal muscle oxidative capacity with aging in long-term calorically restricted rats: Effects are independent of mitochondrial DNA integrity
    Baker, David J.
    Betik, Andrew C.
    Krause, Daniel J.
    Hepple, Russell T.
    [J]. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2006, 61 (07): : 675 - 684
  • [6] Constitutive UCP3 overexpression at physiological levels increases mouse skeletal muscle capacity for fatty acid transport and oxidation
    Bezaire, V
    Spriet, LL
    Campbell, S
    Sabet, N
    Gerrits, M
    Bonen, A
    Harper, ME
    [J]. FASEB JOURNAL, 2005, 19 (06) : 977 - +
  • [7] The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3
    Cadenas, S
    Echtay, KS
    Harper, JA
    Jekabsons, MB
    Buckingham, JA
    Grau, E
    Abuin, A
    Chapman, H
    Clapham, JC
    Brand, MD
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (04) : 2773 - 2778
  • [8] PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
    Canto, Carles
    Auwerx, Johan
    [J]. CURRENT OPINION IN LIPIDOLOGY, 2009, 20 (02) : 98 - 105
  • [9] Chen SL, 2000, GENE DEV, V14, P1209
  • [10] Paradoxical effects of increased expression of PGC-1α on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism
    Choi, Cheol Soo
    Befroy, Douglas E.
    Codella, Roberto
    Kim, Sheene
    Reznick, Richard M.
    Hwang, Yu-Jin
    Liu, Zhen-Xiang
    Lee, Hui-Young
    Distefano, Alberto
    Samuel, Varman T.
    Zhang, Dongyan
    Cline, Gary W.
    Handschin, Christoph
    Lin, Jiandie
    Petersen, Kitt F.
    Spiegelman, Bruce M.
    Shulman, Gerald I.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (50) : 19926 - 19931
12345