Mesenchymal stem cells to treat type 1 diabetes

被引：35
作者：
Pixley, John S. [1 ]
机构：
[1] Texas Tech Univ, Hlth Sci Ctr, Dept Med, Div Rheumatol Immunol, 3601 4th St,MS 9410, Lubbock, TX 79430 USA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2020年 / 1866卷 / 04期
关键词：
Stem cells; Mesenchymal stem cells; Type; 1; diabetes; BONE-MARROW DIFFERENTIATE; UMBILICAL-CORD; STROMAL CELLS; BETA-CELLS; IN-VITRO; ISLET TRANSPLANTATION; AUTOIMMUNE-DISEASES; INSULIN PRODUCTION; HUMAN HEPATOCYTES; CELLULAR-THERAPY;
D O I：
10.1016/j.bbadis.2018.10.033
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
What is clear is we are in the era of the stem cell and its potential in ameliorating human disease. Our perspective is generated from an in vivo model in a large animal that offers significant advantages (complete transplantation tolerance, large size and long life span). This review is an effort to meld our preclinical observations with others for the reader and to outline potential avenues to improve the present outlook for patients with diabetes. This effort exams the history or background of stem cell research in the laboratory and the clinic, types of stem cells, pluripotency or lack thereof based on a variety of pre-clinical investigations attempting endocrine pancreas recovery using stem cell transplantation. The focus is on the use of hematopoietic and mesenchymal stem cells. This review will also examine recent clinical experience following stem cell transplantation in patients with type 1 diabetes.
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页数：16
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