Column selection for pharmaceutical analyses based on a column classification using four test parameters

被引：31

作者：

Koczian, Kristof

Haghedooren, Erik

Dragovic, Sanja

Noszal, Bela

Hoogmartens, Jos

Adams, Erwin ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Lab Farmaceut Anal, Onderzoek Navorsing 2,Postbus 923,Herestr 49, B-3000 Louvain, Belgium

[2] Semmelweis Univ, Dept Pharmaceut Chem, Hungarian Acad Sci, Res Grp Narcot Drugs & Dopings, H-1092 Budapest, Hungary

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2007年 / 44卷 / 04期

关键词：

chromatographic tests; column ranking; fluoxetine; gemcitabine;

D O I：

10.1016/j.jpba.2007.04.015

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This paper focuses on the usability of a previously developed column classification system, applied to pharmaceutical analyses. The separation of two drugs from their respective related substances was investigated on 65 new reversed-phase liquid chromatographic columns. The chromatographic procedure for fluoxetine hydrochloride was performed according to the method prescribed in the European Pharmacopoeia monograph while the separation of gemcitabine hydrochloride was carried out according to the United States Pharmacopeia monograph. It was shown that the column ranking system is a helpful tool in the selection of a suitable column. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：894 / 905

页数：12

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