A Personalized Medicine Approach for Asian Americans with the Aldehyde Dehydrogenase 2*2 Variant

被引:105
作者
Gross, Eric R. [1 ]
Zambelli, Vanessa O. [2 ]
Small, Bryce A. [1 ]
Ferreira, Julio C. B. [3 ]
Chen, Che-Hong [4 ]
Mochly-Rosen, Daria [4 ]
机构
[1] Stanford Univ, Sch Med, Dept Anesthesiol Perioperat & Pain Med, Stanford, CA 94305 USA
[2] Butantan Inst, Lab Pain & Signaling, BR-05503900 Sao Paulo, Brazil
[3] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, BR-05508000 Sao Paulo, Brazil
[4] Stanford Univ, Sch Med, Dept Chem & Syst Biol, Stanford, CA 94305 USA
来源
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 55 | 2015年 / 55卷
关键词
ALDH2; Asian; cancer; ischemia; alcohol; precision medicine; prediction in pharmacology; MYOCARDIAL-INFARCTION PATIENTS; ALCOHOL-METABOLIZING ENZYMES; CORONARY-ARTERY-DISEASE; GENOME-WIDE ASSOCIATION; GENE; PANCREATIC-CANCER; RISK-FACTOR; REPRODUCTIVE TOXICITY; ALDH2; POLYMORPHISMS; ALZHEIMERS-DISEASE;
D O I
10.1146/annurev-pharmtox-010814-124915
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Asian Americans are one of the fastest-growing populations in the United States. A relatively large subset of this population carries a unique loss-of-function point mutation in aldehyde dehydrogenase 2 (ALDH2), ALDH2*2. Found in approximately 560 million people of East Asian descent, ALDH2*2 reduces enzymatic activity by approximately 60% to 80% in heterozygotes. Furthermore, this variant is associated with a higher risk for several diseases affecting many organ systems, including a particularly high incidence relative to the general population of esophageal cancer, myocardial infarction, and osteoporosis. In this review, we discuss the pathophysiology associated with the ALDH2*2 variant, describe why this variant needs to be considered when selecting drug treatments, and suggest a personalized medicine approach for Asian American carriers of this variant. We also discuss future clinical and translational perspectives regarding ALDH2*2 research.
引用
收藏
页码:107 / +
页数:7
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