Asian Americans are one of the fastest-growing populations in the United States. A relatively large subset of this population carries a unique loss-of-function point mutation in aldehyde dehydrogenase 2 (ALDH2), ALDH2*2. Found in approximately 560 million people of East Asian descent, ALDH2*2 reduces enzymatic activity by approximately 60% to 80% in heterozygotes. Furthermore, this variant is associated with a higher risk for several diseases affecting many organ systems, including a particularly high incidence relative to the general population of esophageal cancer, myocardial infarction, and osteoporosis. In this review, we discuss the pathophysiology associated with the ALDH2*2 variant, describe why this variant needs to be considered when selecting drug treatments, and suggest a personalized medicine approach for Asian American carriers of this variant. We also discuss future clinical and translational perspectives regarding ALDH2*2 research.
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Univ Nottingham, Div Stroke, Stroke Trials Unit, Nottingham NG5 1PB, England
Nottingham Univ Hosp NHS Trust, Dept Stroke, Nottingham, EnglandUniv Nottingham, Div Stroke, Stroke Trials Unit, Nottingham NG5 1PB, England
Ankolekar, Sandeep
Fuller, Michael
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East Midlands Ambulance Serv NHS Trust, Nottingham, EnglandUniv Nottingham, Div Stroke, Stroke Trials Unit, Nottingham NG5 1PB, England
Fuller, Michael
Cross, Ian
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East Midlands Ambulance Serv NHS Trust, Nottingham, EnglandUniv Nottingham, Div Stroke, Stroke Trials Unit, Nottingham NG5 1PB, England
Cross, Ian
Renton, Cheryl
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Univ Nottingham, Div Stroke, Stroke Trials Unit, Nottingham NG5 1PB, EnglandUniv Nottingham, Div Stroke, Stroke Trials Unit, Nottingham NG5 1PB, England
Renton, Cheryl
Cox, Patrick
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Univ Nottingham, Div Stroke, Stroke Trials Unit, Nottingham NG5 1PB, EnglandUniv Nottingham, Div Stroke, Stroke Trials Unit, Nottingham NG5 1PB, England
Cox, Patrick
Sprigg, Nikola
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Univ Nottingham, Div Stroke, Stroke Trials Unit, Nottingham NG5 1PB, England
Nottingham Univ Hosp NHS Trust, Dept Stroke, Nottingham, EnglandUniv Nottingham, Div Stroke, Stroke Trials Unit, Nottingham NG5 1PB, England
Sprigg, Nikola
Siriwardena, A. Niroshan
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East Midlands Ambulance Serv NHS Trust, Nottingham, England
Lincoln Univ, Sch Hlth & Social Care, Lincoln, EnglandUniv Nottingham, Div Stroke, Stroke Trials Unit, Nottingham NG5 1PB, England
Siriwardena, A. Niroshan
Bath, Philip M.
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Univ Nottingham, Div Stroke, Stroke Trials Unit, Nottingham NG5 1PB, England
Nottingham Univ Hosp NHS Trust, Dept Stroke, Nottingham, EnglandUniv Nottingham, Div Stroke, Stroke Trials Unit, Nottingham NG5 1PB, England
机构:
Univ Nottingham, Div Stroke, Stroke Trials Unit, Nottingham NG5 1PB, England
Nottingham Univ Hosp NHS Trust, Dept Stroke, Nottingham, EnglandUniv Nottingham, Div Stroke, Stroke Trials Unit, Nottingham NG5 1PB, England
Ankolekar, Sandeep
Fuller, Michael
论文数: 0引用数: 0
h-index: 0
机构:
East Midlands Ambulance Serv NHS Trust, Nottingham, EnglandUniv Nottingham, Div Stroke, Stroke Trials Unit, Nottingham NG5 1PB, England
Fuller, Michael
Cross, Ian
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h-index: 0
机构:
East Midlands Ambulance Serv NHS Trust, Nottingham, EnglandUniv Nottingham, Div Stroke, Stroke Trials Unit, Nottingham NG5 1PB, England
Cross, Ian
Renton, Cheryl
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h-index: 0
机构:
Univ Nottingham, Div Stroke, Stroke Trials Unit, Nottingham NG5 1PB, EnglandUniv Nottingham, Div Stroke, Stroke Trials Unit, Nottingham NG5 1PB, England
Renton, Cheryl
Cox, Patrick
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h-index: 0
机构:
Univ Nottingham, Div Stroke, Stroke Trials Unit, Nottingham NG5 1PB, EnglandUniv Nottingham, Div Stroke, Stroke Trials Unit, Nottingham NG5 1PB, England
Cox, Patrick
Sprigg, Nikola
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h-index: 0
机构:
Univ Nottingham, Div Stroke, Stroke Trials Unit, Nottingham NG5 1PB, England
Nottingham Univ Hosp NHS Trust, Dept Stroke, Nottingham, EnglandUniv Nottingham, Div Stroke, Stroke Trials Unit, Nottingham NG5 1PB, England
Sprigg, Nikola
Siriwardena, A. Niroshan
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h-index: 0
机构:
East Midlands Ambulance Serv NHS Trust, Nottingham, England
Lincoln Univ, Sch Hlth & Social Care, Lincoln, EnglandUniv Nottingham, Div Stroke, Stroke Trials Unit, Nottingham NG5 1PB, England
Siriwardena, A. Niroshan
Bath, Philip M.
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h-index: 0
机构:
Univ Nottingham, Div Stroke, Stroke Trials Unit, Nottingham NG5 1PB, England
Nottingham Univ Hosp NHS Trust, Dept Stroke, Nottingham, EnglandUniv Nottingham, Div Stroke, Stroke Trials Unit, Nottingham NG5 1PB, England