Direct ortho-Acylation of Azoxybenzenes with Aldehydes via Palladium-Catalyzed Regioselective C-H Bond Activation

被引：22

作者：

Yi, Meiling ^{[1
]}

Cui, Xiuling ^{[1
,2
]}

Zhu, Chongwei ^{[1
]}

Pi, Chao ^{[1
]}

Zhu, Weimin ^{[1
]}

Wu, Yangjie ^{[1
]}

机构：

[1] Zhengzhou Univ, Henan Univ, Henan Key Lab Chem Biol & Organ Chem, Key Lab Appl Chem,Dept Chem, Zhengzhou 450052, Peoples R China

[2] Huaqiao Univ, Inst Mol Med, Sch Biomed Sci, Xiamen Key Lab Ocean & Gene Drugs, Xiamen 361021, Fujian, Peoples R China

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 4卷 / 01期

基金：

美国国家科学基金会;

关键词：

aldehydes; azoxybenzenes; CH activation; ortho-acylation; palladium; DECARBOXYLATIVE ORTHO-ACYLATION; ALPHA-OXOCARBOXYLIC ACIDS; O-METHYL OXIMES; OXIDATIVE ORTHO-ACYLATION; LIQUID-CRYSTAL; DIRECT ACCESS; ORTHO-ALKOXYLATION; COMPOSITE FILMS; AZOBENZENE; ARYL;

D O I：

10.1002/ajoc.201402251

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient and convenient palladium catalyzed the ortho-acylation of azoxybenzenes has been developed. Easily available aldehydes were used as a cheap and ideal aroyl sources. This method provides a practical and direct pathway to synthesize 2-acylated azoxybenzenes in chemo- and regioselective manners via palladium-catalyzed CH bond activation. Various substituents on both coupling partners are tolerated well.

引用

页码：38 / 41

页数：4

共 53 条

[1] 2-PHOTON CLEAVAGE OF BENZIL IN THE LASER-JET - INTERMOLECULAR REACTIONS OF TRANSIENT BENZOYL AND TERT-BUTOXY RADICALS IN THE PHOTOLYSIS OF TERT-BUTYL PEROXIDE MIXTURES [J].