Antimicrobial Resistance in Mycobacterium tuberculosis: The Odd One Out

被引：76

作者：

Eldholm, Vegard ^{[1
]}

Balloux, Francois ^{[2
]}

机构：

[1] Norwegian Inst Publ Hlth, Div Infect Dis Control, Lovisenberggata 8, N-0456 Oslo, Norway

[2] UCL, Dept Genet Evolut & Environm, Darwin Bldg,Gower St, London WC1E 6BT, England

来源：

TRENDS IN MICROBIOLOGY | 2016年 / 24卷 / 08期

关键词：

POST PRIMARY TUBERCULOSIS; DRUG-RESISTANCE; ANTIBIOTIC-RESISTANCE; GENOMIC ANALYSIS; LEPROSY PATIENTS; HIV-INFECTION; EVOLUTION; TRANSMISSION; MUTATION; ENGLAND;

D O I：

10.1016/j.tim.2016.03.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antimicrobial resistance (AMR) threats are typically represented by bacteria capable of extensive horizontal gene transfer (HGT). One clear exception is Mycobacterium tuberculosis (Mtb). It is an obligate human pathogen with limited genetic diversity and a low mutation rate which lacks any evidence for HGT. Such features should, in principle, reduce its ability to rapidly evolve AMR. We identify key features in its biology and epidemiology that allow it to overcome its low adaptive potential. We focus in particular on its innate resistance to drugs, its unusual life cycle, including an often extensive latent phase, and its ability to shelter from exposure to antimicrobial drugs within cavities it induces in the lungs.

引用

页码：637 / 648

页数：12

共 91 条

[1] Evolution, Population Structure, and Phylogeography of Genetically Monomorphic Bacterial Pathogens [J].

Achtman, Mark .

ANNUAL REVIEW OF MICROBIOLOGY, 2008, 62 :53-70

[2]

[Anonymous], 2013, Wkly Epidemiol Rec, V88, P365

[3]

[Anonymous], 1987, TUBERCLE, V68, P19

[4] Human tuberculosis predates domestication in ancient Syria [J].

Baker, Oussama ;

Lee, Oona Y. -C. ;

Wu, Houdini H. T. ;

Besra, Gurdyal S. ;

Minnikin, David E. ;

Llewellyn, Gareth ;

Williams, Christopher M. ;

Maixner, Frank ;

O'Sullivan, Niall ;

Zink, Albert ;

Chamel, Berenice ;

Khawam, Rima ;

Coqueugniot, Eric ;

Helmer, Daniel ;

Le Mort, Francoise ;

Perrin, Pascale ;

Gourichon, Lionel ;

Dutailly, Bruno ;

Palfi, Gyoergy ;

Coqueugniot, Helene ;

Dutour, Olivier .

TUBERCULOSIS, 2015, 95 :S4-S12

[5] The spectrum of latent tuberculosis: rethinking the biology and intervention strategies [J].

Barry, Clifton E., III ;

Boshoff, Helena I. ;

Dartois, Veronique ;

Dick, Thomas ;

Ehrt, Sabine ;

Flynn, JoAnne ;

Schnappinger, Dirk ;

Wilkinson, Robert J. ;

Young, Douglas .

NATURE REVIEWS MICROBIOLOGY, 2009, 7 (12) :845-855

[6] Global dissemination of the Mycobacterium tuberculosis W-Beijing family strains [J].

Bifani, PJ ;

Mathema, B ;

Kurepina, NE ;

Kreiswirth, BN .

TRENDS IN MICROBIOLOGY, 2002, 10 (01) :45-52

[7] Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis [J].

Bos, Kirsten I. ;

Harkins, Kelly M. ;

Herbig, Alexander ;

Coscolla, Mireia ;

Weber, Nico ;

Comas, Inaki ;

Forrest, Stephen A. ;

Bryant, Josephine M. ;

Harris, Simon R. ;

Schuenemann, Verena J. ;

Campbell, Tessa J. ;

Majander, Kerttu ;

Wilbur, Alicia K. ;

Guichon, Ricardo A. ;

Steadman, Dawnie L. Wolfe ;

Cook, Della Collins ;

Niemann, Stefan ;

Behr, Marcel A. ;

Zumarraga, Martin ;

Bastida, Ricardo ;

Huson, Daniel ;

Nieselt, Kay ;

Young, Douglas ;

Parkhill, Julian ;

Buikstra, Jane E. ;

Gagneux, Sebastien ;

Stone, Anne C. ;

Krause, Johannes .

NATURE, 2014, 514 (7523) :494-+

[8] Genetic characterization of compensatory evolution in strains carrying rpoB Ser531Leu, the rifampicin resistance mutation most frequently found in clinical isolates [J].

Brandis, Gerrit ;

Hughes, Diarmaid .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2013, 68 (11) :2493-2497

[9] Whole-genome sequencing to identify transmission of Mycobacterium abscessus between patients with cystic fibrosis: a retrospective cohort study [J].

Bryant, Josephine M. ;

Grogono, Dorothy M. ;

Greaves, Daniel ;

Foweraker, Juliet ;

Roddick, Iain ;

Inns, Thomas ;

Reacher, Mark ;

Haworth, Charles S. ;

Curran, Martin D. ;

Harris, Simon R. ;

Peacock, Sharon J. ;

Parkhill, Julian ;

Floto, R. Andres .

LANCET, 2013, 381 (9877) :1551-1560

[10] Evolution of Extensively Drug-Resistant Tuberculosis over Four Decades: Whole Genome Sequencing and Dating Analysis of Mycobacterium tuberculosis Isolates from KwaZulu-Natal [J].

Cohen, Keira A. ;

Abeel, Thomas ;

McGuire, Abigail Manson ;

Desjardins, Christopher A. ;

Munsamy, Vanisha ;

Shea, Terrance P. ;

Walker, Bruce J. ;

Bantubani, Nonkqubela ;

Almeida, Deepak V. ;

Alvarado, Lucia ;

Chapman, Sinead B. ;

Mvelase, Nomonde R. ;

Duffy, Eamon Y. ;

Fitzgerald, Michael G. ;

Govender, Pamla ;

Gujja, Sharvari ;

Hamilton, Susanna ;

Howarth, Clinton ;

Larimer, Jeffrey D. ;

Maharaj, Kashmeel ;

Pearson, Matthew D. ;

Priest, Margaret E. ;

Zeng, Qiandong ;

Padayatchi, Nesri ;

Grosset, Jacques ;

Young, Sarah K. ;

Wortman, Jennifer ;

Mlisana, Koleka P. ;

O'Donnell, Max R. ;

Birren, Bruce W. ;

Bishai, William R. ;

Pym, Alexander S. ;

Earl, Ashlee M. .

PLOS MEDICINE, 2015, 12 (09)

← 1 2 3 4 5 6 7 8 9 10 →