Synthesis of 2H-Indazoles via Tandem Palladium-Catalyzed Deacylative Cross-Coupling and Denitrogenative Cyclization of 2-Iodoazoarenes and 2-Iodoaryltriazenes with Acyldiazoacetates in One-Pot

被引：36

作者：

Yong, Woo-Soon ^{[1
]}

Park, Sangjune ^{[1
]}

Yun, Hyunsik ^{[1
]}

Lee, Phil Ho ^{[1
]}

机构：

[1] Kangwon Natl Univ, Dept Chem, Natl Creat Res Initiat, Ctr Catalyt Organ React, Chunchon 24341, South Korea

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2016年 / 358卷 / 12期

基金：

新加坡国家研究基金会;

关键词：

diazoacetates; 2H-indazoles; 2-iodoazoarenes; palladium catalysis; tandem reactions; N BOND FORMATION; C-H FUNCTIONALIZATION; SULFONYL AZIDES; 1,3-DIPOLAR CYCLOADDITION; DIAZO-COMPOUNDS; AZOBENZENES; HYDROAMINATIONS; 1H-INDAZOLES; EFFICIENT; ALKYNES;

D O I：

10.1002/adsc.201600351

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A synthetic method to prepare a wide range of 2H-indazoles was developed via a tandem palladium-catalyzed deacylative cross-coupling reaction of 2-iodoazoarenes and 2-iodoaryltriazenes with acyldiazoacetates and denitrogenative cyclization reaction of in situ generated diazoacetates having azoaryl and triazenylaryl moieties in one-pot. Additionally, azoaryl-substituted diazoacetates underwent palladium-catalyzed denitrogenative cyclization to produce 2H-indazoles. The present reaction is a good example in which a Pd(0)-catalyst is involved in two catalytic cycles in one-pot.

引用

收藏

页码：1958 / 1967

页数：10

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