Solvent-free Synthesis and Crystal Structure of 2,2′-Dialkyl Bis(3-methyl-6,7-dihydrobenzofuran-4(5H)-one) Derivatives

被引：2

作者：

Ding Ze-Jian ^{[1
]}

Zhang Feng ^{[1
]}

Xu Tian-Xiao ^{[1
]}

Wang Wen-Bin ^{[1
]}

Jin Lei ^{[1
]}

Huang Nian-Yu ^{[1
]}

机构：

[1] China Three Gorges Univ, Coll Biol & Pharmaceut Sci, Hubei Key Lab Nat Prod Res & Dev, Yichang, Hubei 443002, Peoples R China

来源：

CHINESE JOURNAL OF STRUCTURAL CHEMISTRY | 2017年 / 36卷 / 07期

基金：

中国国家自然科学基金;

关键词：

X-ray diffraction; crystal structure; bis(2-tetrahydrobenzofuranyl)alkane; cytotoxic activity; synthesis; BIOLOGICAL EVALUATION; BISABOLANGELONE;

D O I：

10.14102/j.cnki.0254-5861.2011-1480

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of 2,2'-dialkyl bis(3-methyl-6,7-dihydrobenzofuran-4(5H)-one) derivatives was prepared through H2SO4 center dot SiO2 catalyzed condensation reaction under solvent-free conditions as potential anti-tumor agents. All of them were characterized by ESI-MS, IR and NMR spectra. Meanwhile, the single crystal of the target compound (4b), C24H28O4, was also obtained and determined by X-ray crystallography. Crystal data: triclinic system, space group P (1) over bar, a = 8.463(10), b = 9.612(11), c = 13.828(15) angstrom, alpha = 74.29(5), beta = 80.93(5), gamma = 69.90(3)circle, V = 1014(2) angstrom(3), Z = 2, F(000) = 408, D-c = 1.246 g/cm(3), mu = 0.084 mm(-1), R = 0.0883 and wR = 0.2440 for 4616 independent reflections (R-int = 0.1200) and 3490 observed ones (I > 2 sigma(I)).

引用

页码：1124 / 1129

页数：6

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