The characterization of thin films based on chitosan and tannic acid mixture for potential applications as wound dressings

被引：47
作者：
Kaczmarek, B. [1 ]
Nadolna, K. [1 ]
Owczarek, A. [1 ]
Michalska-Sionkowska, M. [2 ]
Sionkowska, A. [1 ]
机构：
[1] Nicolaus Copernicus Univ Torun, Fac Chem, Dept Chem Biomat & Cosmet, Gagarin 7, PL-87100 Torun, Poland
[2] Nicolaus Copernicus Univ Torun, Fac Biol & Environm Protect, Dept Environm Microbiol & Biotechnol, Lwowska 1, PL-87100 Torun, Poland
来源：
POLYMER TESTING | 2019年 / 78卷
关键词：
Chitosan; Tannic acid; Thin films; Blood compatibility; HYDROGEL; ALGINATE;
D O I：
10.1016/j.polymertesting.2019.106007
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Natural polymers can be used to produce materials for biomedical application. In this study, polymeric blends based on chitosan and tannic acid in the form of thin films were obtained. They were characterized for the potential application as wound dressings. Thereby, the thermal stability, maximum tensile strength and water vapor permeability were measured. Moreover, the blood compatibility was determined as the erythrocytes hemolysis rate. The results showed that the addition of tannic acid to chitosan improves the physicochemical properties of the film. The maximum tensile strength and water vapor permeation rate were improved. The hemolysis rate was higher for films with a higher amount of tannic acid than for those containing pure chitosan, however, the value was below 5%, which allows for the medical application of the proposed materials as wound dressings.
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页数：4
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