A self optimizing synthetic organic reactor system using real-time in-line NMR spectroscopy

被引：215

作者：

Sans, Victor ^{[1
]}

Porwol, Luzian ^{[1
]}

Dragone, Vincenza ^{[1
]}

Cronin, Leroy ^{[1
]}

机构：

[1] Univ Glasgow, WestCHEM, Sch Chem, Glasgow G12 8QQ, Lanark, Scotland

来源：

CHEMICAL SCIENCE | 2015年 / 6卷 / 02期

基金：

英国工程与自然科学研究理事会;

关键词：

FLOW; OPTIMIZATION; CHEMISTRY; MICROREACTORS; LAB;

D O I：

10.1039/c4sc03075c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A configurable platform for synthetic chemistry incorporating an in-line benchtop NMR that is capable of monitoring and controlling organic reactions in real-time is presented. The platform is controlled via a modular LabView software control system for the hardware, NMR, data analysis and feedback optimization. Using this platform we report the real-time advanced structural characterization of reaction mixtures, including F-19, C-13, DEPT, 2D NMR spectroscopy (COSY, HSQC and F-19-COSY) for the first time. Finally, the potential of this technique is demonstrated through the optimization of a catalytic organic reaction in real-time, showing its applicability to self-optimizing systems using criteria such as stereoselectivity, multi-nuclear measurements or 2D correlations.

引用

页码：1258 / 1264

页数：7

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