Japanese Lung Cancer Registry Study First Prospective Enrollment of a Large Number of Surgical and Nonsurgical Cases in 2002

Purpose: To investigate prognoses of lung cancer patients prospectively enrolled in the Japan Lung Cancer Registry Study Methods: Patients newly diagnosed as having lung cancer exclusively in 2002 were enrolled Follow-up surveys were performed twice. in 2004 and 2009, and the final follow-up data with prognoses were analyzed for 14,695 patients (79%) Clinical stages were defined according to the sixth edition of the International Union Against Cancer-tumor, node, metastasis classification (2002). Results: The mean age was 67 1 years (range, 18-89 years), and there were 10,194 men (69 3%) and 4315 women (29 7%) The most frequent histology was adenocarcinoma (n = 8325, 56 7%), followed by squamous cell carcinoma (a = 3778, 26%) and small cell carcinoma (a = 1345, 9 2%) The distribution of clinical stages was as follows IA, 4245 cases (29 3%), IB. 2248 (14 5%), IIA. 208 (1 4%), IIB, 918 (6 3%), IIIA, 1700 (11 8%). IIIB, 2110 (16 3%), and IV, 3037 (21 0%) The 5-year survival rates were 44.3% for all patients, 46 8% for those with non-small cell lung cancer, and 14 7% for those with small cell lung cancer According to the clinical stage of non-small cell lung cancer and small cell lung cancer, the 5-year survival rates were 794 and 52 7% for stage IA, 569 and 39 3% for IB, 49.0 and 31 7% for IA. 423 and 29.9% for IIB, 309 and 17 2% for IIIA, 167 and 12 4% for IIIB, and 58 and 3 8% for IV, respectively Conclusion: Analysis of a large cohort in the Japanese registry study found that stage-specific prognosis was within a range similar to other reports The data presented should provide an important reference for future clinical trials in Japan