Crosstalk between NK cells and hepatic stellate cells in liver fibrosis

被引：26

作者：

Zhang, Yang ^{[1
]}

Wu, Yuan ^{[2
]}

Shen, Wenjuan ^{[3
]}

Wang, Bingyu ^{[4
,5
]}

Yuan, Xingxing ^{[4
,5
]}

机构：

[1] Heilongjiang Univ Tradit Chinese Med, Dept Gastroenterol, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R China

[2] Heilongjiang Univ Tradit Chinese Med, Grad Sch, Harbin 150001, Heilongjiang, Peoples R China

[3] Heilongjiang Univ Tradit Chinese Med, Dept Gynaecol, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R China

[4] Heilongjiang Acad Tradit Chinese Med, Dept Gastroenterol, Harbin 150001, Heilongjiang, Peoples R China

[5] Heilongjiang Acad Tradit Chinese Med, Dept Gastroenterol, 33 West Dazhi St, Harbin 150001, Heilongjiang, Peoples R China

来源：

MOLECULAR MEDICINE REPORTS | 2022年 / 25卷 / 06期

基金：

中国国家自然科学基金;

关键词：

natural killer cells; fibrosis; hepatic stellate cells; crosstalk; TGF-beta; INJURY; INFLAMMATION; INHIBITION; ACTIVATION; SINUSOIDS; APOPTOSIS; PATHWAY; ROLES; TRAIL;

D O I：

10.3892/mmr.2022.12724

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Liver fibrosis is a common pathological process of chronic liver diseases, including viral hepatitis and alcoholic liver disease, and ultimately progresses to irreversible cirrhosis and cancer. Hepatic stellate cells (HSCs) are activated to produce amounts of collagens in response to liver injury, thus triggering the initiation and progression of fibrogenesis. Natural killer (NK) cells serve as the essential component of hepatic innate immunity and are considered to alleviate fibrosis by killing activated HSCs. Current antifibrotic interventions have improved fibrosis, but fail to halt its progression in the advanced stage. Clarifying the interaction between NK cells and HSCs will provide clues to the pathogenesis and potential therapies for advanced liver fibrosis.

引用

页数：7

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