Deep brain stimulation and continuous dopaminergic stimulation in advanced Parkinson's disease

被引：11

作者：

Wolters, Erik Ch ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Ctr Med, Dept Neurol, Amsterdam, Netherlands

来源：

PARKINSONISM & RELATED DISORDERS | 2007年 / 13卷

关键词：

Parkinson's disease; treatment options; deep brain stimulation; continuous dopaminergic stimulation;

D O I：

10.1016/j.parkreldis.2007.06.006

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Patients receiving oral levodopa, the standard treatment for Parkinson's disease (PD), eventually develop motor fluctuations and dyskinesias. Treatment options for patients with these symptoms include high-frequency deep brain stimulation of the subthalamic nucleus (STN-DBS) or continuous dopaminergic stimulation (CDS). STN-DBS is the prevalent surgical therapy for PD and has shown efficacy, but behavioural disorders, including cognitive problems, depression and suicidality have been reported. CDs can be achieved with oral dopamine agonists with a long half-life, transdermal or subcutaneous delivery of dopamine agonists, or intestinal levodopa infusion. Of these, duodenal levodopa infusion appears to be the most promising option in terms of both efficacy and safety. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：S18 / S23

页数：6

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