The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome

被引：869
|
作者：
Aird, WC
机构：
[1] Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA
[2] Harvard Univ, Sch Med, Boston, MA 02215 USA
来源：
BLOOD | 2003年 / 101卷 / 10期
关键词：
D O I：
10.1182/blood-2002-06-1887
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Severe sepsis, defined as sepsis with acute organ dysfunction, is associated with high morbidity and mortality rates. The development of novel therapies for sepsis is critically dependent on an understanding of the basic mechanisms of the disease. The pathophysiology of severe sepals involves a highly complex, integrated response that includes the activation of a number of cell types, inflammatory mediators, and the hemostatic system. Central to this process is an alteration of endothellal cell function. The goals of this article are to (1) provide an overview of sepals and its complications, (2) discuss the role of the endothellum in orchestrating the host response in sepsis, and (3) emphasize the potential value of the endothellum as a target for sepsis therapy. (C) 2003 by The American Society of Hematology.
引用
收藏
页码：3765 / 3777
页数：13
相关论文
共 50 条
  • [21] Multiple Organ Dysfunction Syndrome Caused by Sepsis: Risk Factor Analysis
    Sun, Guo-Dong
    Zhang, Yang
    Mo, Shan-Shan
    Zhao, Ming-Yan
    INTERNATIONAL JOURNAL OF GENERAL MEDICINE, 2021, 14 : 7159 - 7164
  • [22] Plasma carnitine levels in sepsis and multiple organ dysfunction syndrome (MODS)
    GarnachoMontero, J
    OrtizLeyba, C
    JimenezJimenez, FJ
    FernandezVega, MD
    PerezParedes, C
    GarciaGarmendia, JL
    9TH EUROPEAN CONGRESS ON INTENSIVE CARE MEDICINE, 1996, : 365 - 369
  • [23] The multiple organ dysfunction syndrome and late-phase mortality in sepsis
    Englert J.A.
    Fink M.P.
    Current Infectious Disease Reports, 2005, 7 (5) : 335 - 341
  • [24] Sepsis and multiple organ dysfunction in burn
    Sabrina F Henrich
    Tatiana H Rech
    Iuri C Wawrzeniak
    Rafael B Moraes
    Karen F Prado
    Marcos C Boniatti
    Denise Matter
    Lívia Biason
    Geisiano Custódio
    Roberto Ritter
    Critical Care, 17 (Suppl 4):
  • [25] A systematic review of experimental treatments for mitochondrial dysfunction in sepsis and multiple organ dysfunction syndrome
    Dare, Anna J.
    Phillips, Anthony R. J.
    Hickey, Anthony J. R.
    Mittal, Anubhav
    Loveday, Benjamin
    Thompson, Nichola
    Windsor, John A.
    FREE RADICAL BIOLOGY AND MEDICINE, 2009, 47 (11) : 1517 - 1525
  • [26] New or Progressive Multiple Organ Dysfunction Syndrome as Surrogate Outcome for Mortality in Pediatric Severe Sepsis Trials Reply
    Lin, John C.
    Spinella, Philip C.
    Fitzgerald, Julie C.
    Tucci, Marisa
    Bush, Jenny L.
    Nadkarni, Vinay M.
    Thomas, Neal J.
    Weiss, Scott L.
    PEDIATRIC CRITICAL CARE MEDICINE, 2017, 18 (05) : 501 - 502
  • [27] Successful treatment with fecal microbiota transplantation in patients with multiple organ dysfunction syndrome and diarrhea following severe sepsis
    Wei, Yanling
    Yang, Jun
    Wang, Jun
    Yang, Yang
    Huang, Juan
    Gong, Hao
    Cui, Hongli
    Chen, Dongfeng
    CRITICAL CARE, 2016, 20
  • [28] Successful treatment with fecal microbiota transplantation in patients with multiple organ dysfunction syndrome and diarrhea following severe sepsis
    Yanling Wei
    Jun Yang
    Jun Wang
    Yang Yang
    Juan Huang
    Hao Gong
    Hongli Cui
    Dongfeng Chen
    Critical Care, 20
  • [29] Role of multiple organ dysfunction syndrome in ARDS mortality
    FS Dias
    N Almeida
    IC Wawrzeniack
    PB Nery
    Critical Care, 6 (Suppl 1):
  • [30] Pathogenesis and management of multiple organ dysfunction or failure in severe sepsis and septic shock
    Balk, RA
    CRITICAL CARE CLINICS, 2000, 16 (02) : 337 - +
12345