Convertible Organic Nanoparticles for Near-Infrared Photothermal Ablation of Cancer Cells

被引：479

作者：

Yang, Jaemoon ^{[1
,3
]}

Choi, Jihye ^{[2
]}

Bang, Doyeon ^{[2
]}

Kim, Eunjung ^{[2
]}

Lim, Eun-Kyung ^{[2
]}

Park, Huiyul ^{[4
]}

Suh, Jin-Suck ^{[1
,3
]}

Lee, Kwangyeol ^{[5
]}

Yoo, Kyung-Hwa ^{[4
]}

Kim, Eun-Kyung ^{[2
]}

Huh, Yong-Min ^{[1
,3
]}

Haam, Seungjoo ^{[2
,3
]}

机构：

[1] Yonsei Univ, Dept Radiol, Seoul 120752, South Korea

[2] Yonsei Univ, Dept Chem & Biomol Engn, Seoul 120749, South Korea

[3] YUHS KRIBB Med Convergence Res Inst, Seoul 120752, South Korea

[4] Yonsei Univ, Dept Phys, Seoul 120749, South Korea

[5] Korea Univ, Dept Chem, Seoul 136701, South Korea

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

cancer; nanoparticles; near-infrared light; photothermal agents; polymers; POLYANILINE; THERAPY; POLYMERS;

D O I：

10.1002/anie.201005075

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Infiltrate and destroy: In an environment rich in protonating or oxidative species, such as the intracellular milieu of cancer cells, the main absorption band of spherical, water-soluble polyaniline nanoparticles was red-shifted to a near-infrared (NIR) wavelength as a result of the formation of the emeraldine salt (see picture). The doped nanoparticles caused photothermal ablation of cancer cells upon NIR laser irradiation in vitro and in vivo. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：441 / 444

页数：4

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