Convertible Organic Nanoparticles for Near-Infrared Photothermal Ablation of Cancer Cells

被引：473

作者：

Yang, Jaemoon ^{[1
,3
]}

Choi, Jihye ^{[2
]}

Bang, Doyeon ^{[2
]}

Kim, Eunjung ^{[2
]}

Lim, Eun-Kyung ^{[2
]}

Park, Huiyul ^{[4
]}

Suh, Jin-Suck ^{[1
,3
]}

Lee, Kwangyeol ^{[5
]}

Yoo, Kyung-Hwa ^{[4
]}

Kim, Eun-Kyung ^{[2
]}

Huh, Yong-Min ^{[1
,3
]}

Haam, Seungjoo ^{[2
,3
]}

机构：

[1] Yonsei Univ, Dept Radiol, Seoul 120752, South Korea

[2] Yonsei Univ, Dept Chem & Biomol Engn, Seoul 120749, South Korea

[3] YUHS KRIBB Med Convergence Res Inst, Seoul 120752, South Korea

[4] Yonsei Univ, Dept Phys, Seoul 120749, South Korea

[5] Korea Univ, Dept Chem, Seoul 136701, South Korea

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

cancer; nanoparticles; near-infrared light; photothermal agents; polymers; POLYANILINE; THERAPY; POLYMERS;

D O I：

10.1002/anie.201005075

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Infiltrate and destroy: In an environment rich in protonating or oxidative species, such as the intracellular milieu of cancer cells, the main absorption band of spherical, water-soluble polyaniline nanoparticles was red-shifted to a near-infrared (NIR) wavelength as a result of the formation of the emeraldine salt (see picture). The doped nanoparticles caused photothermal ablation of cancer cells upon NIR laser irradiation in vitro and in vivo. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：441 / 444

页数：4

共 25 条

[1] Polyaniline, an electroactive polymer, supports adhesion and proliferation of cardiac myoblasts
Bidez, PR
Li, SX
MacDiarmid, AG
Venancio, EC
Wei, Y
Lelkes, PI
[J]. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2006, 17 (1-2) : 199 - 212
[2] Immuno gold nanocages with tailored optical properties for targeted photothermal destruction of cancer cells
Chen, Jingyi
Wang, Danling
Xi, Jiefeng
Au, Leslie
Siekkinen, Andy
Warsen, Addie
Li, Zhi-Yuan
Zhang, Hui
Xia, Younan
Li, Xingde
[J]. NANO LETTERS, 2007, 7 (05) : 1318 - 1322
[3] Doping of polyaniline by transition-metal salts
Dimitriev, OP
[J]. MACROMOLECULES, 2004, 37 (09) : 3388 - 3395
[4] Cancer nanotechnology: Opportunities and challenges
Ferrari, M
[J]. NATURE REVIEWS CANCER, 2005, 5 (03) : 161 - 171
[5] Conducting polymers as free radical scavengers
Gizdavic-Nikolaidis, M
Travas-Sejdic, J
Bowmaker, GA
Cooney, RP
Kilmartin, PA
[J]. SYNTHETIC METALS, 2004, 140 (2-3) : 225 - 232
[6] Heeger A.J., 2001, Angew. Chem, V113, P2660
[7] Heeger AJ, 2001, ANGEW CHEM INT EDIT, V40, P2591, DOI 10.1002/1521-3773(20010716)40:14<2591::AID-ANIE2591>3.0.CO
[8] 2-0
[9] Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance
Hirsch, LR
Stafford, RJ
Bankson, JA
Sershen, SR
Rivera, B
Price, RE
Hazle, JD
Halas, NJ
West, JL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (23) : 13549 - 13554
[10] Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods
Huang, XH
El-Sayed, IH
Qian, W
El-Sayed, MA
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (06) : 2115 - 2120

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