What can eye movements tell us about Symbol Digit substitution by patients with schizophrenia?

Substitution tests are sensitive to cognitive impairment and reliably discriminate patients with schizophrenia from healthy individuals better than most other neuropsychological instruments. However, due to their multifaceted nature, substitution test scores cannot pinpoint the specific cognitive deficits that lead to poor performance. The current study investigated eye movements during performance on a substitution test in order to better understand what aspect of substitution test performance underlies schizophrenia-related impairment. Twenty-five patients with schizophrenia and 25 healthy individuals performed a computerized version of the Symbol Digit Modalities Test while their eye movements were monitored. As expected, patients achieved lower overall performance scores. Moreover, analysis of participants' eye movements revealed that patients spent more time searching for the target symbol every time they visited the key area. Patients also made more visits to the key area for each response that they made. Regression analysis suggested that patients' impaired performance on substitution tasks is primarily related to a less efficient visual search and, secondarily, to impaired memory. (C) 2010 Elsevier B.V. All rights reserved.