Direct electrochemical detection of clozapine by RuO2 nanoparticles-modified screen-printed electrode

被引：11

作者：

Aftatoonian, Mohammad Reza ^{[1
,2
]}

Tajik, Somayeh ^{[1
,3
]}

Mohtat, Bita ^{[4
]}

Aftatoonian, Behnaz ^{[1
]}

Shoaie, Iran Sheikh ^{[5
]}

Beitoltahi, Hadi ^{[6
]}

Zhang, Kaigiang ^{[7
]}

Jang, Ho Won ^{[7
]}

Shokouhimehr, Mohammadreza ^{[7
]}

机构：

[1] Kerman Univ Med Sci, Neurosci Res Ctr, Kerman, Iran

[2] Kerman Univ Med Sci, Leishmaniasis Res Ctr, Kerman, Iran

[3] Kerman Univ Med Sci, Res Ctr Trop & Infect Dis, Kerman, Iran

[4] Islamic Azad Univ, Dept Chem, Karaj Branch, Karaj, Iran

[5] Shahid Bahonar Univ Kerman, Fac Sci, Dept Chem, Kerman 76175133, Iran

[6] Grad Univ Adv Technol, Inst Sci & High Technol & Environm Sci, Environm Dept, Kerman, Iran

[7] Seoul Natl Univ, Res Inst Adv Mat, Dept Mat Sci & Engn, Seoul 08826, South Korea

来源：

RSC ADVANCES | 2020年 / 10卷 / 22期

基金：

新加坡国家研究基金会;

关键词：

GLASSY-CARBON ELECTRODE; REDUCED GRAPHENE OXIDE; AMPEROMETRIC DETECTION; LIQUID-CHROMATOGRAPHY; GREEN SYNTHESIS; HEXACYANOCOBALTATE; NANOCOMPOSITE; NANOTUBES;

D O I：

10.1039/d0ra00778a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This study introduces the sensitive electrochemical detection of clozapine with the use of a ruthenium(iv) oxide nanoparticle (RuO2 NP)-modified screen-printed electrode (RuO2 NPs/SPE). The electrochemical behaviors of clozapine at RuO2 NP/SPE have been examined via cyclic voltammetry (CV), differential pulse voltammetry (DPV) and chronoamperometry (CHA). According to the results, the modified electrode has been accompanied by a decreasing over-potential (ca. 170 mV) and enhancement in the peak current (3 times) in comparison with the bare SPE. The results indicated that RuO2 NP/SPE markedly augmented electro-catalytic activities toward clozapine oxidation. In addition, linear responses have been observed in the range between 0.2 and 500.0 mu M with a sensitivity of 0.076 mu A mu M-1 and a limitation of detection of 0.07 mu M (3 sigma). Moreover, the successful application of RuO2 NP/SPE has been seen in detecting clozapine in real samples, which showed satisfied recoveries. Therefore, outputs suggest that RuO2 NP/SPE will be promising for functional utilization.

引用

页码：13021 / 13028

页数：8

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