Anodic C(sp3)-H Acyloxylation of Indolin-3-ones Enabled by Oxidant-Free Cross-Dehydrogenative C(sp3)-O Coupling

被引：15
|
作者：
Zou, Canlin [1 ]
Wu, Hongting [1 ]
He, Jiangtao [1 ]
Hu, Yunfei [1 ]
Deng, Weijie [1 ]
Li, Xinling [1 ]
Hu, Jinhui [1 ]
Li, Yibiao [1 ]
Huang, Yubing [1 ]
机构：
[1] Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529090, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 87卷 / 02期
基金：
中国国家自然科学基金;
关键词：
C-H; ELECTROORGANIC CHEMISTRY; OXIDATION; ALKALOIDS; INDOLES; CYCLIZATION; ANNULATION; KETONES; AMINES;
D O I：
10.1021/acs.joc.1c02644
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient anodic C(sp(3))-H acyloxylation protocol has been established via intermolecular cross-dehydrogenative C(sp(3))-O coupling. The protocol provides various C2-acyloxy indolin-3-ones without the addition of metal catalysts and external oxidants because indolin-3-ones can be directly oxidized at the anode. The effective application of several medical drugs and the realization of the gram-scale experiment have proven the practicality of this protocol.
引用
收藏
页码：1335 / 1347
页数：13
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