Plants as a source of anti-cancer and anti-HIV agents

被引：56

作者：

Cragg, GM ^{[1
]}

Newman, DJ ^{[1
]}

机构：

[1] NCI, Nat Prod Branch, Dev Therapeut Program, Div Canc Treatment & Diagnosis, Ft Detrick, MD 21702 USA

来源：

ANNALS OF APPLIED BIOLOGY | 2003年 / 143卷 / 02期

关键词：

AIDS; cancer; drugs; HIV; plant products;

D O I：

10.1111/j.1744-7348.2003.tb00278.x

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Plant-derived compounds have played an important role in the development of several clinically useful anti-cancer agents. These include vinblastine, vincristine, the camptothecin derivatives, topotecan and irinotecan, etoposide, and paclitaxel (Taxol(R)). Several promising new agents are in clinical development based on selective activity against cancer-related molecular targets, including flavopiridol and Combretastatin A4 phosphate. Recently, plants have yielded several agents showing anti-AIDS activity, and one of these, (+)-calanolide A, is in clinical development.

引用

页码：127 / 133

页数：7

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