Association between long non-coding RNA polymorphisms and cancer risk: a meta-analysis

被引：55
作者：
Huang, Xin [1 ]
Zhang, Weiyue [2 ]
Shao, Zengwu [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Orthopaed, Wuhan 430022, Hubei, Peoples R China
[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Endocrinol, Wuhan 430022, Hubei, Peoples R China
来源：
BIOSCIENCE REPORTS | 2018年 / 38卷
基金：
中国国家自然科学基金;
关键词：
PROSTATE-CANCER; GENETIC-VARIANTS; GASTRIC-CANCER; HEPATOCELLULAR-CARCINOMA; CHINESE POPULATION; SUSCEPTIBILITY; EXPRESSION; 8Q24; DISEASE; MALAT1;
D O I：
10.1042/BSR20180365
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Several studies have suggested that long non-coding RNA (lncRNA) gene polymorphisms are associated with cancer risk. In the present study, we conducted a meta-analysis related to studies on the association between lncRNA single-nucleotide polymorphisms (SNPs) and the overall risk of cancer. A total of 12 SNPs in five common lncRNA genes were finally included in the meta-analysis. In the lncRNA antisense non-coding RNA (lncRNA) in the INK4 locus (ANRIL), the rs1333048 NC, rs4977574 A/G, and rs10757278 A/G polymorphisms, but not rs1333045 C/T, were correlated with overall cancer risk. Our study also demonstrated that other SNPs were correlated with overall cancer risk, namely, metastasis-associated lung adenocarcinoma transcript 1 (MALAT1, rs619586 A/G), HOXA distal transcript antisense RNA (HOTTIP, rs1859168 NC), and highly up-regulated in liver cancer (HULC, rs7763881 A/C). Moreover, four prostate cancer-associated ncRNA 1 (PRNCR1, rs16901946 GIA, rs13252298 GIA, rs1016343 T/C, and rs1456315 GIA) SNPs were in association with cancer risk. No association was found between the PRNCR1 (rs7007694 UT) SNP and the risk of cancer. In conclusion, our results suggest that several studied lncRNA SNPs are associated with overall cancer risk. Therefore, they might be potential predictive biomarkers for the risk of cancer. More studies based on larger sample sizes and more IncRNA SNPs are warranted to confirm these findings.
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页数：13
相关论文
共 45 条
[31]   Association analyses of genetic variants in long non-coding RNA MALAT1 with breast cancer susceptibility and mRNA expression of MALAT1 in Chinese Han population [J].
Peng, Rui ;
Luo, Chenglin ;
Guo, Qiaoyun ;
Cao, Jingjing ;
Yang, Qian ;
Dong, Kaiyan ;
Wang, Shuaibing ;
Wang, Kaijuan ;
Song, Chunhua .
GENE, 2018, 642 :241-248
[32]   Evolution and Functions of Long Noncoding RNAs [J].
Ponting, Chris P. ;
Oliver, Peter L. ;
Reik, Wolf .
CELL, 2009, 136 (04) :629-641
[33]   The rs11515 Polymorphism Is More Frequent and Associated With Aggressive Breast Tumors with Increased ANRIL and Decreased p16INK4a Expression [J].
Royds, Janice A. ;
Pilbrow, Anna P. ;
Ahn, Antonio ;
Morrin, Helen R. ;
Frampton, Chris ;
Russell, I. Alasdair ;
Moravec, Christine S. ;
Sweet, Wendy E. ;
Tang, W. H. Wilson ;
Currie, Margaret J. ;
Hung, Noelyn A. ;
Slatter, Tania L. .
FRONTIERS IN ONCOLOGY, 2016, 5
[34]   Multiple independent genetic variants in the 8q24 region are associated with prostate cancer risk [J].
Salinas, Claudia A. ;
Kwon, Erika ;
Carlson, Christopher S. ;
Koopmeiners, Joseph S. ;
Feng, Ziding ;
Karyadi, Danielle M. ;
Ostrander, Elaine A. ;
Stanford, Janet L. .
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2008, 17 (05) :1203-1213
[35]  
Sattarifard H, 2017, MOL CLIN ONCOL, V7, P1152, DOI 10.3892/mco.2017.1462
[36]   Association of rs6983267 at 8q24, HULC rs7763881 polymorphisms and serum lncRNAs CCAT2 and HULC with colorectal cancer in Egyptian patients [J].
Shaker, Olfat G. ;
Senousy, Mahmoud A. ;
Elbaz, Eman M. .
SCIENTIFIC REPORTS, 2017, 7
[37]   Association of ANRIL gene polymorphisms with prostate cancer and benign prostatic hyperplasia in an Iranian population [J].
Taheri, Mohammad ;
Pouresmaeili, Farkhondeh ;
Omrani, Mir Davood ;
Habibi, Mohsen ;
Sarrafzadeh, Shaghayegh ;
Noroozi, Rezvan ;
Rakhshan, Azadeh ;
Sayad, Arezou ;
Ghafouri-Fard, Soudeh .
BIOMARKERS IN MEDICINE, 2017, 11 (05) :413-422
[38]   A Lead ANRIL Polymorphism Is Associated with Elevated CRP Levels in Periodontitis: A Pilot Case-Control Study [J].
Teeuw, Wijnand J. ;
Laine, Marja L. ;
Bizzarro, Sergio ;
Loos, Bruno G. .
PLOS ONE, 2015, 10 (09)
[39]   Clinical value of lncRNA MALAT1 as a prognostic marker in human cancer: systematic review and meta-analysis [J].
Tian, Xiaoling ;
Xu, Guoxiong .
BMJ OPEN, 2015, 5 (09)
[40]   The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation [J].
Tripathi, Vidisha ;
Ellis, Jonathan D. ;
Shen, Zhen ;
Song, David Y. ;
Pan, Qun ;
Watt, Andrew T. ;
Freier, Susan M. ;
Bennett, C. Frank ;
Sharma, Alok ;
Bubulya, Paula A. ;
Blencowe, Benjamin J. ;
Prasanth, Supriya G. ;
Prasanth, Kannanganattu V. .
MOLECULAR CELL, 2010, 39 (06) :925-938
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