Association between long non-coding RNA polymorphisms and cancer risk: a meta-analysis

被引：56

作者：

Huang, Xin ^{[1
]}

Zhang, Weiyue ^{[2
]}

Shao, Zengwu ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Orthopaed, Wuhan 430022, Hubei, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Endocrinol, Wuhan 430022, Hubei, Peoples R China

来源：

BIOSCIENCE REPORTS | 2018年 / 38卷

基金：

中国国家自然科学基金;

关键词：

PROSTATE-CANCER; GENETIC-VARIANTS; GASTRIC-CANCER; HEPATOCELLULAR-CARCINOMA; CHINESE POPULATION; SUSCEPTIBILITY; EXPRESSION; 8Q24; DISEASE; MALAT1;

D O I：

10.1042/BSR20180365

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several studies have suggested that long non-coding RNA (lncRNA) gene polymorphisms are associated with cancer risk. In the present study, we conducted a meta-analysis related to studies on the association between lncRNA single-nucleotide polymorphisms (SNPs) and the overall risk of cancer. A total of 12 SNPs in five common lncRNA genes were finally included in the meta-analysis. In the lncRNA antisense non-coding RNA (lncRNA) in the INK4 locus (ANRIL), the rs1333048 NC, rs4977574 A/G, and rs10757278 A/G polymorphisms, but not rs1333045 C/T, were correlated with overall cancer risk. Our study also demonstrated that other SNPs were correlated with overall cancer risk, namely, metastasis-associated lung adenocarcinoma transcript 1 (MALAT1, rs619586 A/G), HOXA distal transcript antisense RNA (HOTTIP, rs1859168 NC), and highly up-regulated in liver cancer (HULC, rs7763881 A/C). Moreover, four prostate cancer-associated ncRNA 1 (PRNCR1, rs16901946 GIA, rs13252298 GIA, rs1016343 T/C, and rs1456315 GIA) SNPs were in association with cancer risk. No association was found between the PRNCR1 (rs7007694 UT) SNP and the risk of cancer. In conclusion, our results suggest that several studied lncRNA SNPs are associated with overall cancer risk. Therefore, they might be potential predictive biomarkers for the risk of cancer. More studies based on larger sample sizes and more IncRNA SNPs are warranted to confirm these findings.

引用

页数：13

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