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Subacute effects of 2,4-dichlorophenoxyacetic herbicide on antioxidant defense system and lipid peroxidation in rat erythrocytes
被引:34
|作者:
Wafa, Tayeb
[1
]
Amel, Nakbi
[1
]
Issam, Chargui
[1
]
Imed, Cheraief
[1
]
Abdelhedi, Miled
[2
]
Mohamed, Hammami
[1
]
机构:
[1] Fac Med, Human Nutr & Metab Disorders UR03 ES 08, Biochem Lab, Monastir 5019, Tunisia
[2] CHU Hached, Dept Biochem, Sousse 4002, Tunisia
关键词:
2,4-Dichlorophenoxyacetic acid;
Rat;
Erythrocyte;
Lipid peroxidation;
Oxidative stress;
OXIDATIVE STRESS;
ACID 2,4-D;
FREE-RADICALS;
PHENOXYACETIC HERBICIDES;
ACUTE TOXICITY;
METABOLISM;
PARAMETERS;
DAMAGE;
LIVER;
PROTEIN;
D O I:
10.1016/j.pestbp.2011.01.004
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
The erythrocyte, due to its role as O-2 and CO2 transporter, is under the constant exposure to reactive oxygen species and oxidative stress. The objective of this study was to investigate the ability of 2,4-D to induce oxidative stress in blood of male wistar rats. Rats were randomly divided into four groups: a control group and three treated groups receiving by gavage 15, 75 and 150 mg, respectively, of 2,4-D/kg/BW/day for 28 days. Results showed that 2,4-D caused significant negative changes in the investigated biochemical parameters. In fact, 2,4-D exposition strongly increases LDH, by contrast, there is a statistically significant decrease in Hgb levels. The malondialdehyde level was significantly increased in 2,4-D treated groups. Fatty acid composition of the erythrocytes was also significantly changed with 2,4-D exposure, in favor of the peroxidation of polyunsaturated fatty acids. Furthermore, antioxidant enzyme (SOD, CAT, GPx, and GR) activities in erythrocytes were significantly decreased. Thus, our results indicated the potential effects of 2,4-D to cause oxidative stress in rat erythrocytes. Therefore, at higher doses, 2,4-D may play an important role in the development of vascular disease via lipid peroxidation and oxidative stress. (C) 2011 Elsevier Inc. All rights reserved.
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页码:256 / 264
页数:9
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