Nickel-Catalyzed Removal of Alkene Protecting Group of Phenols, Alcohols via Chain Walking Process

被引：6

作者：

Meng, Chenkai ^{[1
]}

Niu, Haolin ^{[1
]}

Ning, Juehan ^{[1
]}

Wu, Wengang ^{[1
]}

Yi, Jun ^{[1
]}

机构：

[1] Changshu Inst Technol, Sch Mat Engn, Jiangsu Lab Adv Funct Mat, Changshu 215500, Jiangsu, Peoples R China

来源：

MOLECULES | 2020年 / 25卷 / 03期

基金：

中国国家自然科学基金;

关键词：

deprotection; nickel; chain walking; phenol; alcohol; ALLYL ETHERS; REDUCTIVE ARYLATION; INTERNAL OLEFINS; ARYL BROMIDES; DEPROTECTION; REMOTE; ESTERS; MILD; CLEAVAGE; HALIDES;

D O I：

10.3390/molecules25030602

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An efficient nickel-catalyzed removal of alkene protection group under mild condition with high functional group tolerance through chain walking process has been established. Not only phenolic ethers, but also alcoholic ethers can be tolerated with the retention of stereocenter adjacent to hydroxyl group. The new reaction brings the homoallyl group into a start of new type of protecting group.

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页数：12

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