A Novel Approach to Identifying a Neuroimaging Biomarker for Patients With Serious Mental Illness

被引：9

作者：

Madan, Alok ^{[1
,2
]}

Fowler, J. Christopher ^{[2
]}

Patriquin, Michelle A. ^{[1
,2
]}

Salas, Ramiro ^{[2
]}

Baldwin, Philip R. ^{[2
]}

Velasquez, Kenia M. ^{[2
]}

Viswanath, Humsini ^{[2
]}

Molfese, David L. ^{[2
]}

Sharp, Carla ^{[1
,3
]}

Allen, Jon G. ^{[1
,2
]}

Hardesty, Susan ^{[1
,2
]}

Oldham, John M. ^{[1
,2
]}

Frueh, B. Christopher ^{[1
,4
]}

机构：

[1] Menninger Clin, Houston, TX 77035 USA

[2] Baylor Coll Med, Dept Psychiat & Behav Sci, Houston, TX 77030 USA

[3] Univ Houston, Dept Psychol, Houston, TX USA

[4] Univ Hawaii, Dept Psychol, Hilo, HI 96720 USA

来源：

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES | 2017年 / 29卷 / 03期

关键词：

GLOBAL BURDEN; DEPRESSION; CONNECTIVITY; HEALTH; ABUSE;

D O I：

10.1176/appi.neuropsych.16090174

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Serious mental illness (SMI) is disabling, and current interventions are ineffective for many. This exploratory study sought to demonstrate the feasibility of applying topological data analysis (TDA) to resting-state functional connectivity data obtained from a heterogeneous sample of 235 adult inpatients to identify a biomarker of treatment response. TDA identified two groups based on connectivity between the prefrontal cortex and striatal regions: patients admitted with greater functional connectivity between these regions evidenced less improvement from admission to discharge than patients with lesser connectivity between them. TDA identified a potential biomarker of an attenuated treatment response among inpatients with SMI. Insofar as the observed pattern of resting-state functional connectivity collected early during treatment is replicable, this potential biomarker may indicate the need to modify standard of care for a small, albeit meaningful, percentage of patients.

引用

页码：275 / 283

页数：9

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