Nanoribbons self-assembled from short peptides demonstrate the formation of polar zippers between β-sheets

被引：97

作者：

Wang, Meng ^{[1
]}

Wang, Jiqian ^{[1
]}

Zhou, Peng ^{[1
]}

Deng, Jing ^{[2
]}

Zhao, Yurong ^{[1
]}

Sun, Yawei ^{[1
]}

Yang, Wei ^{[1
]}

Wang, Dong ^{[1
]}

Li, Zongyi ^{[3
]}

Hu, Xuzhi ^{[3
]}

King, Stephen M. ^{[4
]}

Rogers, Sarah E. ^{[4
]}

Cox, Henry ^{[3
]}

Waigh, Thomas A. ^{[3
]}

Yang, Jun ^{[2
]}

Lu, Jian Ren ^{[3
]}

Xu, Hai ^{[1
]}

机构：

[1] China Univ Petr East China, Coll Chem Engn, Ctr Bioengn & Biotechnol, 66 Changjiang West Rd, Qingdao 266580, Peoples R China

[2] Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Key Lab Magnet Resonance Biol Syst,Natl Ctr Magne, Wuhan 430071, Hubei, Peoples R China

[3] Univ Manchester, Sch Phys & Astron, Biol Phys Grp, Manchester M13 9PL, Lancs, England

[4] STFC Rutherford Appleton Lab, ISIS Pulsed Neutron Source, Didcot OX11 0QX, Oxon, England

来源：

NATURE COMMUNICATIONS | 2018年 / 9卷

基金：

英国工程与自然科学研究理事会; 中国国家自然科学基金; 欧盟地平线“2020”; “创新英国”项目;

关键词：

AMYLOID FIBRILS; AMINO-ACIDS; NANOSTRUCTURES; POLYMORPHISM; AMPHIPHILES; HANDEDNESS; NANOTUBES; HYDROGELS; MODEL; NMR;

D O I：

10.1038/s41467-018-07583-2

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Peptide self-assembly is a hierarchical process, often starting with the formation of a-helices, beta-sheets or beta-hairpins. However, how the secondary structures undergo further assembly to form higher-order architectures remains largely unexplored. The polar zipper originally proposed by Perutz is formed between neighboring beta-strands of poly-glutamine via their side-chain hydrogen bonding and helps to stabilize the sheet. By rational design of short amphiphilic peptides and their self-assembly, here we demonstrate the formation of polar zippers between neighboring beta-sheets rather than between beta-strands within a sheet, which in turn intermesh the beta-sheets into wide and flat ribbons. Such a super-secondary structural template based on well-defined hydrogen bonds could offer an agile route for the construction of distinctive nanostructures and nanomaterials beyond beta-sheets.

引用

页数：11

共 45 条

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Coenen, Michiel J. J.
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Elemans, Johannes A. A. W.
Hush, Noel S.
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