Preparation of PLGA nanoparticles containing estrogen by emulsification-diffusion method

被引：221

作者：

Kwon, HY ^{[1
]}

Lee, JY ^{[1
]}

Choi, SW ^{[1
]}

Jang, YS ^{[1
]}

Kim, JH ^{[1
]}

机构：

[1] Yonsei Univ, Dept Chem Engn, Nanosphere Proc & Technol Lab, Seoul 120749, South Korea

来源：

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS | 2001年 / 182卷 / 1-3期

基金：

新加坡国家研究基金会;

关键词：

poly; (D; L lactide-co-glycolide) (PLGA); nanoparticle; estrogen; emulsification-diffusion method; didodecyl dimethyl ammonium bromide (DMAB);

D O I：

10.1016/S0927-7757(00)00825-6

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Nano-sized poly (D,L lactide-co-glycolide) (PLGA) particles, widely used as a biodegradable polymeric carrier, containing estrogen were prepared employing emulsification-diffusion method. Estrogen was chosen as a model drug. The preparation method consists of emulsifying a solution of polymer and drug in the aqueous phase containing stabilizer, previously saturated, followed by adding excess water. Influence of process variables on the mean particle size of nanoparticles has been studied. It was clarified that the type and concentrations of stabilizer, homogenizer speed, polymer concentration determined the size of PLGA nanoparticles. Especially when didodecyl dimethyl ammonium bromide (DMAB) was used as a stabilizer, estrogen containing nanoparticles of smaller than 100 nm was obtained. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：123 / 130

页数：8

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